Uniaxial properties of ascending aortic aneurysms in light of effective stretch.

A constitutive model that explicitly considers the gradual recruitment of collagen fibers is applied to investigate the uniaxial properties of human ascending aortic aneurysms. The model uses an effective stretch, which is a continuum scale kinematic variable measuring the true stretch of the tissue, to formulate the fiber stress. The constitutive equation contains two shape parameters characterizing the stochastic distribution of fiber waviness, and two elastic parameters accounting for, respectively, the elastic properties of ground substance and the straightened collagen fibers. The model is applied to 156 sets of uniaxial stress-stretch data obtained from 52 aneurysm samples. Major findings include (1) the uniaxial response can be well described by a quadratic strain energy function of the effective strain; (2) the ultimate stretches, when measured in terms of the effective stretch, are closely clustered around 1.1, in contrast to a much wider range in the original stretch; and (3) the ultimate stress correlates positively with the fiber stiffness. The age dependence and directional differences of constitutive parameters are also investigated. Results indicate that only the waviness depends strongly on age; no clear alterations occur in elastic parameters. Further, the fibers are wavier and stiffer in the circumferential direction than in the longitudinal direction. No other parameters exhibit significant direction difference. STATEMENT OF SIGNIFICANCE: We introduced a constitutive model which explicitly accounts for collagen fiber recruitment to investigate the uniaxial properties of human ascending aortic aneurysm tissues. Uniaxial response data from 156 specimens were considered in the study. It was found that the seemingly dissimilar response curves are, in fact, similar if we measure the deformation using an effective stretch which factors out the uncrimping deformation. The rupture stretches in terms of the effective stretch are closely packed around 1.1. And the stress-stretch curves collapse to a canonical curve after a transformation.