AI Article Synopsis
- - 1H-imidazo[4,5-f][1,10]phenanthroline (IPM713) has shown promising anticancer effects, particularly against the colorectal cancer cell line HCT116, with an IC of 1.7 μM.
- - The study found that IPM713 works by blocking the cell cycle in the G0/G1 phase and inducing cell death (apoptosis) through the inhibition of the PI3K/AKT/mTOR signaling pathway.
- - An acute toxicity test revealed that IPM713 has a high safety profile, with a median lethal dose (LD) above 5000 mg/kg, indicating its potential as a therapeutic agent for colorectal cancer. *
Article Abstract
1H-imidazo[4,5-f][1,10]phenanthroline (IPM713) is a type of tricyclic conjugated rigid planar structure with potential medical applications, but its anticancer activity has not yet been fully studied. In the present research, cells from seven different cancer types were used to study the anticancer effect, and IPM713 was found to inhibit the colorectal cancer cell line HCT116 most significantly, with a half maximal inhibitory concentration (IC) of 1.7 μM. The mechanisms by which IPM713 exerts anti-colorectal cancer activity were studied. IPM713 blocked the cell cycle in G0/G1 phase and induced apoptosis by suppressing the PI3K/AKT/mTOR axis. In addition, an acute toxicity test showed that the median lethal dose (LD) was above 5000 mg/kg. The findings of this research suggest that IPM713 can interfere with the PI3K/AKT/mTOR signaling pathway and might be a potential therapeutic candidate for the treatment of colorectal cancer.
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| http://dx.doi.org/10.1016/j.ejphar.2021.174514 | DOI Listing |
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