The nuclear hormone receptor estrogen receptor alpha (ERα) is a well-known transcription factor present in many breast cancers, where it promotes cancer progression. In this issue of Cell, Xu et al. report that ERα is also an RNA-binding protein and that its post-transcriptional activity enables cancer cell fitness and survival.
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| http://dx.doi.org/10.1016/j.cell.2021.09.012 | DOI Listing |
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Receptor discordance after nipple-sparing mastectomy.
Surg Pract Sci
June 2024
Department of Breast and Endocrine Surgery, Okayama University Hospital, Okayama, Japan.
Background: Recent studies have shown that receptor status of breast cancer change between primary tumor and recurrence, which may influence treatment strategy and prognosis, but there are few reports on receptor discordance between primary tumors and local recurrence (LR) after nipple-sparing mastectomy (NSM).
Patients And Methods: We collected 74 patients who had LR after NSM for newly diagnosed stages 0 to 3 breast cancer between 2008 and 2016 at 14 institutions. We classified into 4 subtypes based on hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2).
Expressional Alternation of 5α-Reductase Type I, P450 Aromatase, and Androgen and Estrogen Receptors in the Mouse Testis Induced by the Lipectomy of the Epididymal Fat at Different Postnatal Ages.
Dev Reprod
December 2024
Department of Biochemistry and Molecular Biology, College of Medicine, Eulji University, Daejeon 34824, Korea.
The epididymal fat is required for the maintenance of normal spermatogenesis, and the lipectomy of epididymal fat at different postnatal age results in disrupted expression patterns of several testicular steroidogenic enzymes. The current research examined the effect of epididymal fat lipectomy at different postnatal ages on expression of cytochrome 5α-reductase I, cytochrome P450 aromatase, androgen receptor (AR), and estrogen receptors (ER) α and β in the mouse testis after 2 weeks of the lipectomy. The lipectomy of epididymal fat at 2 months of postnatal age resulted in significant increases of expression levels of cytochrome 5α-reductase I, cytochrome P450 aromatase, AR, and ER α and β.
View Article and Find Full Text PDFPurpose: To investigate the effects of C-type natriuretic peptide (CNP) on human granulosa cell growth and elucidate its regulatory mechanisms.
Methods: A human non-luteinizing granulosa cell line (HGrC) developed from small antral follicles was used to assess the impact of CNP on cell proliferation and estrogen synthesis. cGMP production via the guanylate cyclase domain of the CNP receptor, natriuretic peptide receptor 2 (NPR2), was confirmed.
Purpose: Uterine leiomyomas (ULMs) are classified into those with and without MED12 mutations (MED12m(+) and MED12m(-), respectively). This study was undertaken to establish a culture system to evaluate the effect of female hormones on the growth of ULM cells in each ULM subtype.
Methods: ULM cells isolated from MED12m(+) or MED12m(-) tissues were cultured in a monolayer for 7 days with four hormone treatments: estrogen (E) and progesterone (P) (E + P), E only (E), P only (P), and medium only (CTRL).
Endocrine treatment mechanisms in triple-positive breast cancer: from targeted therapies to advances in precision medicine.
Front Oncol
January 2025
Department of Medical Oncology, Third Division, Jilin City Second People's Hospital, Jilin, China.
Triple-positive breast cancer (TPBC), defined by the co-expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), poses unique therapeutic challenges due to complex signaling interactions and resulting treatment resistance. This review summarizes key findings on the molecular mechanisms and cross-talk among ER, PR, and HER2 pathways, which drive tumor proliferation and resistance to conventional therapies. Current strategies in TPBC treatment, including endocrine and HER2-targeted therapies, are explored alongside emerging approaches such as immunotherapy and CRISPR/Cas9 gene editing.
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