We present a novel algorithm that allows us to gain detailed insight into the effects of sparsity in linear and nonlinear optimization. Sparsity is of great importance in many scientific areas such as image and signal processing, medical imaging, compressed sensing, and machine learning, as it ensures robustness against noisy data and yields models that are easier to interpret due to the small number of relevant terms. It is common practice to enforce sparsity by adding the l-norm as a penalty term. In order to gain a better understanding and to allow for an informed model selection, we directly solve the corresponding multiobjective optimization problem (MOP) that arises when minimizing the main objective and the l-norm simultaneously. As this MOP is in general non-convex for nonlinear objectives, the penalty method will fail to provide all optimal compromises. To avoid this issue, we present a continuation method specifically tailored to MOPs with two objective functions one of which is the l-norm. Our method can be seen as a generalization of homotopy methods for linear regression problems to the nonlinear case. Several numerical examples - including neural network training - demonstrate our theoretical findings and the additional insight gained by this multiobjective approach.
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http://dx.doi.org/10.1109/TPAMI.2021.3114962 | DOI Listing |
Med Chem
January 2025
Department of Chemistry and Biochemistry, Faculty of Medicine and Pharmacy, Ibn Zohr University, Laayoune 70000, Morocco.
Background: Oxidative stress is strongly linked to neurodegeneration through the activation of c-Abl kinase, which arrests α-synuclein proteolysis by interacting with parkin interacting substrate (PARIS) and aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 (AIMP2). This activation, triggered by ataxia-telangiectasia mutated (ATM) kinase, leads to dopaminergic neuron loss and α-synuclein aggregation, a critical pathophysiological aspect of Parkinson's disease (PD). To halt PD progression, pharmacological inhibition of c-Abl kinase is essential.
View Article and Find Full Text PDFProkinetic agents are drugs used to enhance gastrointestinal motility and treat disorders such as Gastroesophageal Reflux Disease (GERD) and gastroparesis. pH-dependent release systems offer targeted drug delivery, allowing prokinetic agents to be released specifically in desired regions of the gastrointestinal tract. This optimizes drug efficacy and minimizes systemic side effects.
View Article and Find Full Text PDFCurr Med Chem
January 2025
Cukurova University, Faculty of Medicine, Division of Endocrinology, Adana, Turkey.
Introduction: Diabetes mellitus is associated with an increased risk of atherosclerosis related to dyslipidemia. Although the terms hyperlipidemia and Diabetes Mellitus [DM] or diabetic dyslipidemia are interrelated to each other, these two conditions have some differences.
Aim: This study aimed to highlight possible mechanisms of hyperlipidemia and/or dyslipidemia in diabetic patients, which can be treated with available and newer hypolipidemic drugs.
Psychiatr Hung
January 2025
Rosszullétek speciális elme- és ideggyógyászati szakrendelô, Budapest, Hungary, E-mail:
Author analyses the process of care of somatic symptom disorder in the general medical practice with special concern to iatrogenic harms. In his opinion the latency of the patients' first appointment with a psychiatrist or clinical psychologist is caused by multiple factors. Patients do not have knowledge on the basic activities of central nervous system necessary to recognize the pathomechanism.
View Article and Find Full Text PDFGynecol Oncol Rep
February 2025
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Long Island Jewish Medical Center, Zucker School of Medicine at Hofstra/Northwell, Northwell Health, New Hyde Park, NY 11040, United States.
Introduction: Adenoid basal cell carcinoma is a rare cervical malignancy which is indolent in nature but resembles more commonly occurring aggressive malignancies.
Cases: Here we describe three cases of cervical adenoid basal cell carcinoma. All patients had a history of cervical dysplasia with high-risk HPV.
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