The fundamental contribution of James Maxwell Ross Cormack (1909-1975) in suggesting the term "apoptosis".

Apoptosis

Section of Anatomy and History of Medicine, Department of Medicine, University of Udine, P.le Kolbe 3, 33100, Udine, Italy.

Published: October 2021

This study highlights the historical contribution of Professor James Cormack by providing a Greek term that describes the process of programmed cell death. In 1972 the ancient Greek word "apoptosis" first appeared in the scientific literature. This short manuscript will examine the actual meaning of the term and its historical and phylological background. The word "apoptosis" contains a variety of semantic nuances that are perfectly suited to describe such a complex set of biological events as programmed cell death.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10495-021-01688-8DOI Listing

Publication Analysis

Top Keywords

programmed cell
8
cell death
8
word "apoptosis"
8
fundamental contribution
4
contribution james
4
james maxwell
4
maxwell ross
4
ross cormack
4
cormack 1909-1975
4
1909-1975 suggesting
4

Similar Publications

Objectives: PD15, a novel natural steroidal saponin extracted from the rhizomes of Paris delavayi Franchet, has demonstrated a strong cytotoxic effect against HepG2 and U87MG cells. However, its therapeutic effects on colorectal cancer (CRC) and the underlying molecular mechanisms remain unclear.

Methods: MTT assay, clonogenic assay, Hoechst 33258 staining, flow cytometry, molecular docking, and western blot were used to investigate the mechanism of PD15 in HCT116 cell lines.

View Article and Find Full Text PDF

Short-term starvation boosts anti-PD-L1 therapy by reshaping tumor-associated macrophages in hepatocellular carcinoma.

Hepatology

January 2025

Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, People's Republic of China.

Background And Aims: Immune checkpoint inhibitors (ICIs) have revolutionized systemic hepatocellular carcinoma (HCC) treatment. Nevertheless, numerous patients are refractory to ICIs therapy. It is currently unknown whether diet therapies such as short-term starvation (STS) combined with ICIs can be used to treat HCC.

View Article and Find Full Text PDF

Tissue-specific T cell immune responses play a critical role in maintaining organ health but can also drive immune pathology during both autoimmunity and alloimmunity. The mechanisms controlling intratissue T cell programming remain unclear. Here, we leveraged a nonhuman primate model of acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation to probe the biological underpinnings of tissue-specific alloimmune disease using a comprehensive systems immunology approach including multiparameter flow cytometry, population-based transcriptional profiling, and multiplexed single-cell RNA sequencing and TCR sequencing.

View Article and Find Full Text PDF

Primary mitochondrial disorders are most often caused by deleterious mutations in the mitochondrial DNA (mtDNA). Here, we used a mitochondrial DddA-derived cytosine base editor (DdCBE) to introduce a compensatory edit in a mouse model that carries the pathological mutation in the mitochondrial transfer RNA (tRNA) alanine (mt-tRNA) gene. Because the original m.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!