AI Article Synopsis
- Recent studies indicate that DNA methylation changes in various regions, not just promoter areas, during physiological processes and diseases.
- The current research found that black raspberries (BRBs) fed to mice reduced the development of colon and intestinal tumors through hypomethylation in various DNA regions.
- The hypomethylating effects of BRBs stem from a combination of their phytochemicals and gut bacterial metabolites, suggesting that similar benefits could be obtained from other fruits and vegetables.
Article Abstract
Recent studies have suggested that in addition to promoter region, DNA methylation in intragenic and intergenic regions also changes during physiological processes and disease. The current study showed that feeding of black raspberries (BRBs) to mice suppressed colon and intestinal tumors. MBDCap-seq suggested that dietary BRBs hypomethylated promoter, intragenic, and intergenic regions. Annotation of those regions highlighted genes in pathways involved in immune regulation, inflammatory signaling, production of nitric oxide and reactive oxygen species, and progression of colorectal cancer. BRB phytochemicals (e.g., ellagic acid, anthocyanins, oligosaccharides) and their gut bacterial metabolites (e.g., urolithin, protocatechuic acid, short-chain fatty acids) inhibited DNMT1 and DNMT3B activities in a cell-free assay. Our results suggest that BRBs' hypomethylating activities result from the combined effects of multiple BRB phytochemicals and their gut bacterial metabolites. Because similar substances are found in many plant products, our results with BRBs might also apply to commonly consumed fruits and vegetables.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8457619 | PMC |
| http://dx.doi.org/10.1002/fft2.45 | DOI Listing |
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