AI Article Synopsis
- The endoplasmic reticulum (ER) is crucial for protein folding, lipid synthesis, and calcium balance in cells.
- When cells are exposed to reductive agents, it causes stress in the ER that interferes with protein folding and leads to an expanded ER structure.
- However, less is known about the effects of oxidative agents on the ER, which might disrupt lipid metabolism, particularly in the perinuclear region of the organelle.
Article Abstract
The endoplasmic reticulum (ER) is a central organelle in charge of correct protein folding; lipids synthesis, modification, and sorting; as well as of maintenance of calcium homeostasis. To accomplish these functions, the ER lumen possesses an oxidative potential. Challenging cells with reductive agents therefore provokes an ER stress that immediately affects protein folding, and which morphologically manifests by an expansion of the cytoplasmic ER network. Yet less is known about the impact on the ER of exposing cells to oxidative agents, which risk to exacerbate the basal, physiologically oxidative environment. We have monitored the morphology of the ER of in response to this type of treatment. We bring the notion that oxidative agents give rise to diverse alterations in the perinuclear ER subdomain that are suggestive of lipid metabolism perturbations.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8453305 | PMC |
| http://dx.doi.org/10.17912/micropub.biology.000462 | DOI Listing |
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