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Investigating the Relationship Between Anti-seizure Medications and Bleeding Disorders: A Comprehensive Review of the Current Literature.
Drugs Real World Outcomes
January 2025
Kabul University of Medical Sciences, Kabul, Afghanistan.
Anti-seizure medications (ASMs) are specific types of anticonvulsants used to treat epileptic seizures. However, several studies have shown an association between ASMs and an increased risk of hematological disorders, such as thrombocytopenia, aplastic anemia, and platelet function disorders leading to prolonged bleeding times. This review explores the existing literature on this topic, investigating a wide variety of ASMs, ranging from first-generation medications to newer ones.
View Article and Find Full Text PDFModulation of oxidative stress/NMDA/nitric oxide pathway by topiramate attenuates morphine dependence in mice.
Heliyon
December 2024
Department of Biomedical Sciences, Pak Austria Fachhochschule: Institute of Applied Sciences and Technology, Haripur, Khyber Pakhtunkhwa, Pakistan.
Morphine belongs to the class of opioids and is known for its potential to cause dependence and addiction, particularly with prolonged use. Due to the associated risks, caution must be taken when prescribing and limiting its clinical use. Overexpression of N-methyl-D-aspartate (NMDA) receptors, nitric oxide and cGMP pathway has been implicated in exacerbate the development of morphine dependence and withdrawal.
View Article and Find Full Text PDFAssessment of temporal changes in cognitive effects induced by antiseizure medications in epilepsy patients.
Epilepsy Behav
December 2024
Liv Hospital Neurology Department, Kavaklıdere, Bestekar Cd No:8, 06680 Cankaya, Ankara, Turkey.
Objective: Numerous studies have been conducted investigating the effects of antiseizure medications (ASMs) on cognitive functions, and the cognitive side effects of some ASMs have been demonstrated. However, data on whether tolerance to these side effects develops over time is insufficient. The aim of this study is to evaluate the reversibility of cognitive impairments caused by ASMs in patients, utilizing event-related potentials (ERPs) and the Montreal Cognitive Assessment (MoCA) test.
View Article and Find Full Text PDFCharacterizing drug-induced stuttering in electronic health records.
J Commun Disord
November 2024
Vanderbilt Genetics Institute, Vanderbilt University Medical Center, USA.
Article Synopsis
- Drug-induced stuttering is an acquired speech disorder caused by certain medications, resembling developmental stuttering, and has been primarily studied through case reports and adverse drug reactions.
- A recent study analyzed electronic health records from a major medical center to identify and classify drugs linked to this type of stuttering, reviewing 40 suspected cases.
- The findings revealed that 18 different drugs were associated with stuttering in 22 individuals, especially in the classes of antiseizure agents, CNS stimulants, and antidepressants, with topiramate being the most commonly implicated drug; the study emphasizes the need for better documentation of medication-related speech issues in EHRs.
Topiramate Inhibits Capsaicin-Induced Mast Cell Degranulation and CGRP Release in Rat Dura Mater.
Brain Sci
October 2024
Neurosurgery Unit, Federal University of Pernambuco (UFPE), Recife 50670-901, Brazil.
Background/objectives: Migraine is a disease that stands out for its high prevalence and socioeconomic costs. It involves the entire trigeminovascular system, the signaling substances, and their targets. However, the role of meningeal mast cells in migraine is still unclear.
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