AI Article Synopsis
- Scientists studied a drug called ixazomib to improve immune responses after people get bone marrow transplants.
- The drug helped mice live longer and reduced the risk of a serious condition called chronic graft-versus-host disease (cGvHD).
- Ixazomib also boosted certain immune cells while keeping important effects against leukemia, making the immune system work better without causing too many problems.
Article Abstract
In this study, we aimed to modify the immune response in the long term after allogeneic bone marrow transplantation (allo-BMT) by using the proteasome inhibitor ixazomib (IXZ) at the late stages of the post-transplant period. This approach facilitated the immune reconstitution after transplantation. IXZ significantly prolonged survival and decreased the risk of chronic graft-versus-host disease (cGvHD) in two different murine models without hampering the graft-versus-leukemia (GvL) effect, as confirmed by bioluminescence assays. Remarkably, the use of IXZ was related to an increase of regulatory T cells both in peripheral blood and in the GvHD target organs and a decrease of effector donor T cells. Regarding B cells, IXZ treated mice had faster recovery of B cells in PB and of pre-pro-B cells in the bone marrow. Mice receiving ixazomib had a lower number of neutrophils in the GvHD target organs as compared to the vehicle group. In summary, delayed administration of IXZ ameliorated cGvHD while preserving GvL and promoted a pro-tolerogenic immune response after allo-BMT.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8636253 | PMC |
| http://dx.doi.org/10.1038/s41409-021-01452-1 | DOI Listing |
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