Auditory studies in animals benefit from quick and accurate audiometry. The auditory brainstem response (ABR) and prepulse inhibition (PPI) have been widely used for hearing assessment in animals, but how well these assessments predict subjective audiometry still remains unclear. Human studies suggest that subjective audiometry is consistent with the ABR-based audiogram, not with the PPI-based audiogram, likely due to top-down processing in the cortex that inhibits PPI. Here, we challenged this view in Wistar rats, as rodents exhibit less complexity of cortical activities and thereby less influence of the cerebral cortex on PPI compared to humans. To test our hypothesis, we investigated whether subjective audiometry correlates with ABR- or PPI-based audiograms across the range of audible frequencies in Wistar rats. The subjective audiogram was obtained through pure-tone audiometry based on operant conditioning. Our results demonstrated that both the ABR-based and PPI-based audiograms significantly correlated to the subjective audiogram. We also found that ASR strength was information-rich, and adequate interpolation of this data offered accurate audiometry. Thus, unlike in humans, PPI could be used to predict subjective audibility in rats.
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http://dx.doi.org/10.1038/s41598-021-98167-6 | DOI Listing |
JMIR Form Res
January 2025
Faculty of Audiology and Speech Language Pathology, Sri Ramachandra Institute of Higher Education and Research, Chennai, India.
Background: The prevalence of hearing loss in infants in India varies between 4 and 5 per 1000. Objective-based otoacoustic emissions and auditory brainstem response have been used in high-income countries for establishing early hearing screening and intervention programs. Nevertheless, the use of objective screening tests in low- and middle-income countries (LMICs) such as India is not feasible.
View Article and Find Full Text PDFFront Neurol
December 2024
Dizziness Center, Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Objective: Acute unilateral peripheral vestibulopathy or vestibular neuritis (AUPV/VN) manifests as acute onset vertigo, often accompanied by nausea, vomiting, and moderate gait instability. It is suspected when vestibular hypofunction is documented on video-head impulse (video-HITs) and caloric tests in the presence of contralesionally beating horizontal-torsional nystagmus. Herein, we report patients presenting with acute vestibular syndrome (AVS) showing selective otolithic dysfunction in the presence of normal caloric and video-HITs and abnormal enhancement of the peripheral vestibular structures on MRI.
View Article and Find Full Text PDFJ Otol
October 2024
Department of Otolaryngology Head and Neck Surgery, Chinese PLA General Hospital, Beijing, China.
The prevalence of unilateral deafness (SSD) or asymmetric hearing loss (AHL) among patients with hearing impairments ranges from 7.2% to 15.0%, indicating a relatively significant proportion.
View Article and Find Full Text PDFJ Acoust Soc Am
December 2024
Vanderbilt University, Nashville, Tennessee 37232, USA.
This study (1) characterized the effects of channel interaction using spectral blurring, (2) evaluated an image-guided electrode selection (IGES) method aiming to reduce channel interaction, and (3) investigated the impact of electrode placement factors on the change in performance by condition. Twelve adult MED-EL (Innsbruck, Austria) cochlear implant recipients participated. Performance was compared across six conditions: baseline (no blurring), all blurred, apical blurred, middle blurred, basal blurred, and IGES.
View Article and Find Full Text PDFInt J Pediatr Otorhinolaryngol
January 2025
Division of Otology, Department of Otorhinolaryngology & Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; School of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:
Introduction: Despite the reported auditory deficits and developmental challenges in children with unilateral microtia and aural atresia (UMAA), there remains a lack of consensus on early intervention with bone conduction hearing aids (BCHAs) to restore binaural hearing due to the uncertain clinical benefits and intolerability of the conventional devices. Previous studies investigating the auditory benefits under binaural hearing condition were limited and demonstrated controversial opinions in heterogenous patient groups with various devices. Our study aimed to evaluate the audiological performance, including monoaural and binaural hearing, and subjective satisfaction of the ADHEAR system, a novel adhesive BCHA, in experienced pediatric users with UMAA.
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