AI Article Synopsis
- A study in India assessed early COVID-19 incidence in kidney transplant recipients (KTR) and found that 2.6% experienced COVID-19 within 30 days post-transplant, among 838 performed from March 2020 to May 2021.
- Among the 22 KTR patients with early COVID-19, symptoms varied from asymptomatic to severe, with common symptoms including shortness of breath and loss of smell; their mortality rate was not significantly higher than the overall KTR group.
- The findings indicate a greater severity and mortality in COVID-19 among waitlisted patients compared to KTR, suggesting that KTR may have better outcomes, which could inform decisions regarding
Article Abstract
Background: Limited data exist on the incidence and outcome of early coronavirus disease 2019 (COVID-19) in kidney transplantation recipients (KTR).
Methods: A retrospective multicenter research study was conducted across 12 centers in India. We explored the symptomatology, demographic, laboratory findings, and outcome of COVID-19 within 30 days of transplantation. The outcome was compared with the overall KTR and waitlisted patients acquiring COVID-19.
Results: The incidence of early COVID-19 was 2.6% (n = 22) for the cumulative 838 renal transplants performed since nationwide lockdown in March 2020 until May 2021. Overall, 1049 KTR were diagnosed with COVID-19 and 2% of those had early COVID-19. The median age of the early COVID-19 cohort was 43 (31-46) years. COVID-19 severity ranged from asymptomatic (18.2%), mild (59.1%), moderate (9.1%), and severe (13.6%). Among clinical symptoms, dyspnea and anosmia were frequent, and in laboratory parameters, neutrophil lymphocyte ratio, high-sensitivity C-reactive protein, and D-dimer were higher in patients requiring oxygen. The mortality in early COVID-19 was not higher than overall KTR (4.5% vs 8.5%; P = 1). COVID-19 severity (23.9% vs 15.7%; P = .0001) and mortality (15.5% vs 8.5%; P = .001) among waitlisted patients (n = 1703) were higher compared with overall KTR.
Conclusions: We report higher burden of COVID-19 in waitlisted patients compared with KTR and a favorable outcome in early COVID-19 in KTR. Our report will help the transplant physicians in dealing with the ongoing dilemma of halting or resuming transplantation in the COVID-19 era.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8403672 | PMC |
| http://dx.doi.org/10.1016/j.transproceed.2021.08.034 | DOI Listing |
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