The total antioxidant capacity (TAC) has become increasingly vital for evaluating antioxidant food quality in the field of healthcare. Herein, a convenient and sensitive method for TAC assay was proposed based on the absorbance difference of reaction systems between various antioxidants existed in food and Dex-FeMnzyme/oxTMB. Under the optimum condition, the limit of detection (LOD) of the colorimetric sensor was 1.17 μM with the linear concentration range from 1 μM to 30 μM. The analysis results demonstrated the excellent feasibility of practical application in fruit and vegetable food, which offered a new avenue for the establishment of colorimetric biosensors.
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http://dx.doi.org/10.1016/j.foodchem.2021.131115 | DOI Listing |
Chem Biol Interact
January 2025
Anhui Prevention and Control Engineering Research Center for Fatty Liver Disease, Hefei, Anhui, 230032,P. R. China; The Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, China; Inflammation and Immune-Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, China. Electronic address:
Oxidative stress induced by excess ethanol is an important factor in the progression of alcoholic liver disease (ALD). In recent years, inhibiting Kelch-like ECH-associated protein 1 (KEAP1) to activate the antioxidant regulator Nuclear factor erythroid 2-related factor 2 (NRF2) has been considered an effective strategy for treating oxidative stress-related diseases, but its application in ALD remains insufficiently explored. This study aims to discover high-affinity inhibitors targeting the KEAP1 receptor.
View Article and Find Full Text PDFJ Hazard Mater
January 2025
Departamento de Biologia Geral, Universidade Federal de Viçosa, Viçosa, MG, Brazil. Electronic address:
Bee population decline is associated with various stressors, including exposure to pollutants. Among these, titanium dioxide (TiO), an emerging nanoparticle (NP) pollutant, potentially affects living organisms, including bees. This study evaluates the impact of TiO NPs ingestion (1.
View Article and Find Full Text PDFBioorg Chem
January 2025
Laboratorio de Peptidos Bioactivos, Department of Organic Chemistry, Faculty of Biochemistry and Biological Sciences, National University of the Littoral, Ciudad Universitaria UNL, 3000 Santa Fe, Argentina; National Scientific and Technical Research Council (CONICET), Ministry of Science, Technology and Innovation, Godoy Cruz 2290, Ciudad de Buenos Aires, Argentina. Electronic address:
The search for novel cholinesterase inhibitors is essential for advancing treatments for neurodegenerative disorders such as Alzheimer's disease (AD). In this study, we employed the Rosetta pepspec module, originally developed for designing peptides targeting protein-protein interactions, to design de novo peptides targeting the peripheral aromatic site (PAS) of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). A total of nine peptides were designed for human AChE (hAChE), T.
View Article and Find Full Text PDFEcotoxicol Environ Saf
January 2025
Department of Industrial Engineering, University of Applied Sciences Technikum Wien, Hoechstaedtplatz 6, Vienna 1200, Austria. Electronic address:
Lead (Pb), a toxic metal, causes severe health hazards to both humans and plants due to environmental pollution. Biochar addition has been efficiently utilized to enhance growth of plants as well as yield in the presence of Pb-induced stress. The present research introduces a novel use of biochar obtained from the weed Achyranthes japonica to enhance the growth of plants in Pb-contaminated soil.
View Article and Find Full Text PDFNutr Res
January 2025
Health and Nutrition Postgraduate Program, State University of Ceará, Fortaleza, Ceará, Brazil.
Previous evidence suggests that certain types of nuts, when included in a healthy diet pattern, may provide health benefits. Therefore, we hypothesize that the consumption of cashew nuts associated with a healthy diet may enhance antioxidant defenses and improve anthropometric and body composition parameters in individuals with obesity. We conducted a 12-week randomized clinical trial, divided into 4 sessions, involving adolescents randomly assigned to receive either 30 g of roasted cashew nuts together with nutrition education (cashew nut group-CNG) or only nutrition education (control group-CG).
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