AI Article Synopsis
- - Several species of Aristolochia, particularly A. clematitis, were studied for their antimicrobial properties and the concentrations of aristolochic acids I and II (AA I and AA II) across various plant parts.
- - The extracts of A. clematitis were analyzed using high-performance liquid chromatography, revealing the root had the highest concentrations of AA I and II, while the fruit extracts exhibited the strongest antimicrobial activity against Staphylococcus aureus strains.
- - Despite the presence of AA I and II, no direct correlation was established between the concentrations of these acids and the antimicrobial effectiveness of the extracts.
Article Abstract
Introduction: Several Aristolochia species were used as medicinal herb across Europe and in recent years, their antimicrobial activity has also been investigated.
Materials And Methods: In this study, A. clematitis was selected to evaluate the aristolochic acids I and II (AA I and AA II) concentrations and the antimicrobial activity of methanol, hexane, butanol, and ethyl acetate extracts of the root, stem, leaf, root, and fruit. AA I and AA II contents were measured by a validated high-performance liquid chromatography-ultraviolet method.
Results: Each fraction of the plant contained AA I and AA II and the root was found to have the highest contents of AA I (1.09%) and AA II (0.7454%). The minimum inhibitory concentrations of all extracts were determined by standard microdilution method. The fruit's extracts showed the most efficient antimicrobial effect against both methicillin sensitive and resistant Staphylococcus aureus strains.
Conclusion: Correlation between the AA I and AA II concentrations and the antimicrobial effect was not found.
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| http://dx.doi.org/10.1556/019.70.2019.36 | DOI Listing |
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