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Identification of m7G Methylation-Related miRNA Signature Associated with Survival and Immune Microenvironment Regulation in Uterine Corpus Endometrial Carcinoma.
Biomed Res Int
December 2022
Department of Gynecology and Obstetrics, Shanghai Fifth People's Hospital, Fudan University, Shanghai 200240, China.
Background: N-methylguanosine (m7G) has been implicated in the development of cancer. The role of m7G-related miRNAs in the survival prediction of UCEC patients has not been investigated. Current research was the first to construct an m7G-related miRNA model to accurately predict the survival of patients with uterine corpus endometrial carcinoma (UCEC) and to explore immune cell infiltration and immune activity in the tumor microenvironment.
View Article and Find Full Text PDFExtracellular vesicles microRNA-592 of melanoma stem cells promotes metastasis through activation of MAPK/ERK signaling pathway by targeting PTPN7 in non-stemness melanoma cells.
Cell Death Discov
October 2022
Institute of Life Sciences, Chongqing Medical University, Chongqing, China.
Melanoma, one of the most aggressive malignancies, its high mortality and low survival rates are associated with effective metastatic colonization. Melanoma metastasis hinges on the bidirectional cell-cell communication within the complex metastatic microenvironments (MME). Extracellular vesicles (EVs) are recognized as a new class of molecular mediator in MME programing.
View Article and Find Full Text PDFMatrine exerted an anti-tumor effect on acute myeloid leukemia via the lncRNA LINC01116/miR-592-mediated JAK/STAT pathway inactivation.
Neoplasma
January 2022
Department of Hematology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China.
As a malignant hematological cancer, acute myeloid leukemia (AML) influences the health of many people. This study explored the anti-AML activity of matrine (a natural-derived alkaloid), as well as the internal molecular mechanism. In vitro, cell viability, apoptosis, and productions of inflammatory cytokines including IL-1β, IL-6, and TNF-α were tested by MTT, Annexin V-FITC/PI staining, and ELISA, respectively.
View Article and Find Full Text PDFComprehensive Analysis of RNA Expression Profile Identifies Hub miRNA-circRNA Interaction Networks in the Hypoxic Ischemic Encephalopathy.
Comput Math Methods Med
January 2022
Department of Neonatology, Jinan Maternal and Child Health Care Hospital, Shandong, China.
Hypoxic ischemic encephalopathy (HIE) is classified as a sort of serious nervous system syndrome that occurs in the early life period. Noncoding RNAs had been confirmed to have crucial roles in human diseases. So far, there were few systematical and comprehensive studies towards the expression profile of RNAs in the brain after hypoxia ischemia.
View Article and Find Full Text PDFMiR-592 activates the mTOR kinase, ERK1/ERK2 kinase signaling and imparts neuronal differentiation signature characteristic of Group 4 medulloblastoma.
Hum Mol Genet
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Advanced Centre for Treatment, Research & Education in Cancer, Tata Memorial Centre, Navi Mumbai 410210, India.
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