AI Article Synopsis
- Some prebiotics help good bacteria grow, but they can also help some bad bacteria, so researchers tested a specific one called Gal-β1,4-Rha.
- They found that this prebiotic helps a particular good bacteria grow better while stopping some harmful bacteria from growing.
- In experiments with mice, using Gal-β1,4-Rha helped prevent weight loss caused by infections, making it a promising option for future health products.
Article Abstract
Certain existing prebiotics meant to facilitate the growth of beneficial bacteria in the intestine also promote the growth of other prominent bacteria. Therefore, the growth-promoting effects of β-galactosides on intestinal bacteria were analyzed. Galactosyl-β1,4-l-rhamnose (Gal-β1,4-Rha) selectively promoted the growth of subsp. 105-A (JCM 31944) has multiple solute-binding proteins belonging to ATP-binding cassette transporters for sugars. Each strain in the library of 11 subsp. mutants, in which each gene of the solute-binding protein was disrupted, was cultured in a medium containing Gal-β1,4-Rha as the sole carbon source, and only the BL105A_0502 gene-disruption mutant showed delayed and reduced growth compared to the wild-type strain. BL105A_0502 homolog is highly conserved in bifidobacteria. In a Gal-β1,4-Rha-containing medium, subsp. JCM 1222, which possesses BLIJ_2090, a homologous protein to BL105A_0502, suppressed the growth of enteric pathogen , whereas the BLIJ_2090 gene-disrupted mutant did not. , administration of and Gal-β1,4-Rha alleviated infection-related weight loss in mice. We have successfully screened Gal-β1,4-Rha as a next-generation prebiotic candidate that specifically promotes the growth of beneficial bacteria without promoting the growth of prominent bacteria and pathogens.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8475593 | PMC |
| http://dx.doi.org/10.1080/19490976.2021.1973835 | DOI Listing |
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