Background: Feline calicivirus (FCV) is a common pathogen of felids, and FCV vaccination is regularly practiced. The genetic variability and antigenic diversity of FCV hinder the effective control and prevention of infection by vaccination. Improved knowledge of the epidemiological characteristics of FCV should assist in the development of more effective vaccines.
Objectives: This study aims to determine the prevalence of FCV in a population of cats with FCV-suspected clinical signs in Hangzhou and to demonstrate the antigenic and genetic relationships between vaccine status and representative isolated FCV strains.
Methods: Cats (n = 516) from Hangzhou were investigated between 2018 and 2020. The association between risk factors and FCV infection was assessed. Phylogenetic analyses based on a capsid coding sequence were performed to identify the genetic relationships between strains. virus neutralization tests were used to assess antibody levels against isolated FCV strains in client-owned cats.
Results: The FCV-positive rate of the examined cats was 43.0%. Risk factors significantly associated with FCV infection were vaccination status and oral symptoms. Phylogenetic analysis revealed a radial phylogeny with no evidence of temporal or countrywide clusters. There was a significant difference in the distribution of serum antibody titers between vaccinated and unvaccinated cats.
Conclusions: This study revealed a high prevalence and genetic diversity of FCV in Hangzhou. The results indicate that the efficacy of FCV vaccination is unsatisfactory. More comprehensive and refined vaccination protocols are an urgent and unmet need.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8460454 | PMC |
| http://dx.doi.org/10.4142/jvs.2021.22.e73 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Rapid Detection of Feline Calicivirus Using Lateral Flow Dipsticks Based on CRISPR/Cas13a System.
Animals (Basel)
December 2024
The College of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China.
Feline calicivirus (FCV) is one of the most common viral pathogens in domestic cats worldwide, which mainly causes upper respiratory tract infections in felines and seriously threatens the health of felines. Consequently, it is crucial to establish a rapid detection method to efficiently take control and prevent the spread of FCV. To construct the Cas13a-RAA-LFD reaction system, this study specifically designed recombinase-aided amplification (RAA) primers added with a T7 promoter and CRISPR RNA (crRNA), which were both based on the FCV relatively conserved sequence.
View Article and Find Full Text PDFHow Does the Normalization Process After the COVID-19 Pandemic Affect Patients With Obsessive-Compulsive Disorder? A Longitudinal Study.
J Nerv Ment Dis
January 2025
Department of Psychiatry, Kutahya Health Sciences University, Kütahya, Türkiye.
This study aims to investigate the effect of the normalization process after the pandemic on obsessive-compulsive disorder (OCD) patients. During the pandemic period, the Yale-Brown Obsessive Compulsive Scale (Y-BOCS), Padua Inventory-Washington State University Revision, the Fear of COVID-19 Scale (FCV-19S), and an interview form inquiring sociodemographic characteristics were applied to the participant patients with OCD. During the normalization process, the patients were reevaluated after about 1 year.
View Article and Find Full Text PDFAn effectively protective VLP vaccine candidate for both genotypes of feline calicivirus.
Front Immunol
January 2025
State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China.
Feline calicivirus (FCV) is one of the most widespread pathogens affecting feline animals. Currently, FCV is believed to be divisible into two genotypes, with prevalent strains encompassing both GI and GII. Vaccination is the primary means of preventing FCV infection, yet traditional inactivated or attenuated vaccines theoretically pose potential safety concerns.
View Article and Find Full Text PDFUltrasonographic computer-assisted quantification of the intraluminal uterine content in female dogs.
Theriogenology
March 2025
Center of Reproductive Physiology and Diagnostic Imaging, Faculty of Veterinary Sciences of the National University of La Plata, Argentina; CONICET, Argentina.
In dogs, the characterization of intraluminal uterine contents has been subjectively carried out by the operators. The aims of this study were: 1) To ultrasonographically describe and compare the echogenicity and heterogeneity of the intraluminal uterine contents in bitches using digital analysis; 2) To assess the cytology of the uterine contents; 3) To evaluate the effect of clinical, ultrasonographic, bacteriological and cytological parameters on intraluminal contents echogenicity and heterogeneity. Twenty-one intact, 3-24 kg, 1-12 years of age, female dogs with ultrasonographically detected uterine content were included.
View Article and Find Full Text PDFMetalloproteases and their inhibitors in the postpartum endometrial remodeling in dairy cows: their relationship with days to conception after parturition.
Vet Res Commun
December 2024
Facultad de Ciencias Veterinarias (FCV), Universidad Nacional del Litoral (UNL), Esperanza, Santa Fe, Argentina.
In dairy herds, it is expected that cows will be cycling and the uterus will be ready for a new conception before the fourth week postpartum. However, an alteration in the endometrial remodeling can delay conception, increasing the parturition-to-conception interval, and consequently decreasing the reproductive performance. The endometrial matrix has a relevant participation in the processes of postpartum uterine remodeling.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!