Objective: We aimed to evaluate apelin-13 levels, total oxidant/antioxidant status in Alzheimer's disease (AD) and to investigate the relationship between these parameters.
Methods: Patients newly diagnosed with AD were enrolled in the study. The control group consisted of age- and gender-matched healthy individuals. Serum levels of apelin-13, total antioxidant status (TAS), and total oxidant status (TOS) were measured. Oxidative stress index was calculated (TOS/TAS) for each participant.
Results: We reported that serum apelin-13 and TAS values were significantly lower in the AD group compared with controls, and they found a fair but insignificant relationship between Apelin-13 and TAS values.
Conclusion: According to our results, we suggested that insufficient apelin-13 and TAS levels may contribute to the pathogenesis of AD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8444954 | PMC |
| http://dx.doi.org/10.1002/agm2.12173 | DOI Listing |
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