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Institute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Published: September 2021
AI Article Synopsis
SARS-CoV-2 variants are less effectively neutralized by vaccines and monoclonal antibodies, necessitating alternative treatments.
Researchers tested therapeutic equine polyclonal antibodies against five significant variants (alpha, beta, epsilon, gamma, delta) and found they efficiently neutralized these variants at very low concentrations.
Equine polyclonal antibodies offer a promising treatment option due to their effectiveness, broad coverage, low cost, and scalability for COVID-19.
Article Abstract
SARS-CoV-2 variants of concern show reduced neutralization by vaccine-induced and therapeutic monoclonal antibodies; therefore, treatment alternatives are needed. We tested therapeutic equine polyclonal antibodies (pAbs) that are being assessed in clinical trials in Costa Rica against five globally circulating variants of concern: alpha, beta, epsilon, gamma and delta, using plaque reduction neutralization assays. We show that equine pAbs efficiently neutralize the variants of concern, with inhibitory concentrations in the range of 0.146-1.078 μg/mL, which correspond to extremely low concentrations when compared to pAbs doses used in clinical trials. Equine pAbs are an effective, broad coverage, low-cost and a scalable COVID-19 treatment.
