Challenging behaviors constitute a real pitfall in supporting people with severe intellectual disabilities. Undermining patients and host institutions as well as psychiatric services, these crisis situations are usually underpinned by many factors including somatic, psychiatric, educational and environmental factors. New models, including the one developed by our team in Lausanne, offer a more specific approach for these complex cases, involving individualized, collaborative and multidisciplinary care to resolve the crisis but also for the overall improvement of the person's life course. This article aims to present the model set up by the Psychiatry Department of the CHUV (UPCHM unit).
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Environ Sci Pollut Res Int
January 2025
Department of Agricultural Engineering, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi, India.
Drought is one of the most detrimental natural calamities to the economy. Despite its significant consequences, the evolution from meteorological to agricultural and hydrological droughts still needs to be explored. A thorough investigation was carried out in India's eastern hills and plateau region to determine the extent of drought's impact through indices.
View Article and Find Full Text PDFActa Paediatr
January 2025
Center for Chronically Sick Children, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Aim: To describe the long-term neurodevelopmental outcomes of asphyxiated neonates treated with hypothermia in association with neonatal magnetic resonance imaging (MRI) findings.
Methods: We evaluated, retrospectively, clinical and radiological single-centre data at 0, 2, and 5 years of age of 53 asphyxiated neonates born between 2005 and 2015. Neonatal cranial MRI was re-evaluated using the Weeke score ranging from 0 (normal finding) to 55 (cerebral devastation) by a single neuroradiologist blinded to patient outcomes.
Hum Mol Genet
January 2025
Department of Cell & Developmental Biology, Vanderbilt University School of Medicine, 1161 21st Ave S, Nashville, Tennessee, 37232, United States of America.
Tuberous Sclerosis Complex (TSC) is a debilitating developmental disorder characterized by a variety of clinical manifestations. While benign tumors in the heart, lungs, kidney, and brain are all hallmarks of the disease, the most severe symptoms of TSC are often neurological, including seizures, autism, psychiatric disorders, and intellectual disabilities. TSC is caused by loss of function mutations in the TSC1 or TSC2 genes and consequent dysregulation of signaling via mechanistic Target of Rapamycin Complex 1 (mTORC1).
View Article and Find Full Text PDFIntellect Dev Disabil
February 2025
Michelle Menezes, Jessica Pappagianopoulos, and Micah O. Mazurek, University of Virginia.
This study sought to compare frequency of paid work by autistic adolescents to paid work by adolescents with other neurodevelopmental disorders and typically developing adolescents, and to examine whether demographic and clinical characteristics were associated with autistic adolescent employment with data from 2016-2019 National Survey of Children's Health. Rate of paid work was significantly lower in the autistic group (22.01%) than typically developing (49.
View Article and Find Full Text PDFEpilepsia
January 2025
IRCCS Institute of Neurological Sciences of Bologna, Full Member of the European Reference Network EpiCARE, Bologna, Italy.
Objective: This study aimed to identify prescribing behaviors in women of childbearing potential (WOCP) with epilepsy already taking valproate (VPA), and to investigate the relationship between VPA maintenance, substitution, reduction, or withdrawal as part of polytherapy, and seizure worsening or relapse.
Methods: We retrospectively reviewed the prescription behaviors and seizure outcomes in WOCP (16-50 years of age) with epilepsy, referred to eight Italian epilepsy centers, who were taking VPA for at least 1 year between 2014 and 2019.
Results: Among 750 women (~12% of all WOCP), 528 (70.
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