The past 18 months has been filled with transitions for healthcare organizations, for nurses, and for the patients and families they care for. As we transition from the real and virtual confines inflicted by the pandemic, the light shines on gratitude for relationships cultivated and the hope they bring.
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Child Death and Mothers' Subsequent Mental Health in a High-Mortality African Community.
Popul Dev Rev
December 2024
Partners in Hope, Lilongwe, Malawi.
Despite declines in child mortality rates, experiencing a child death remains a common feature of motherhood in many contemporary African populations. Yet, we lack population insights into the consequences of child death for mothers' well-being in the high-mortality regions where it concentrates. Contrasting an extensive psychology literature on the severe and long-lasting consequences of child death for parents in low-mortality settings, a long-standing thesis in multiple social science literature is that the normativity of child death in high-mortality settings can lead to a numbing effect-muting parents' reactions to child loss.
View Article and Find Full Text PDFDrug repurposing using artificial intelligence, molecular docking, and hybrid approaches: A comprehensive review in general diseases vs Alzheimer's disease.
Comput Methods Programs Biomed
January 2025
Bioinformatics Programme, Institute of Biological Sciences, Faculty of Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia; Centre of Research in System Biology, Structural, Bioinformatics and Human Digital Imaging (CRYSTAL), Universiti Malaya, Kuala Lumpur 50603, Malaysia. Electronic address:
Background: Alzheimer's disease (AD), the most prevalent form of dementia, remains enigmatic in its origins despite the widely accepted "amyloid hypothesis," which implicates amyloid-beta peptide aggregates in its pathogenesis and progression. Despite advancements in technology and healthcare, the incidence of AD continues to rise. The traditional drug development process remains time-consuming, often taking years to bring an AD treatment to market.
View Article and Find Full Text PDFSurvival strategies of cancer cells: the role of macropinocytosis in nutrient acquisition, metabolic reprogramming, and therapeutic targeting.
Autophagy
January 2025
Department of General Surgery, Aerospace Center Hospital, Beijing, China.
Macropinocytosis is a nonselective form of endocytosis that allows cancer cells to largely take up the extracellular fluid and its contents, including nutrients, growth factors, etc. We first elaborate meticulously on the process of macropinocytosis. Only by thoroughly understanding this entire process can we devise targeted strategies against it.
View Article and Find Full Text PDFThe lived experience of postpartum depression and psychosis in women: a bottom-up review co-written by experts by experience and academics.
World Psychiatry
February 2025
Department of Psychiatry, University of Campania "L. Vanvitelli", Naples, Italy.
This is the first bottom-up review of the lived experience of postpartum depression and psychosis in women. The study has been co-designed, co-conducted and co-written by experts by experience and academics, drawing on first-person accounts within and outside the medical field. The material initially identified was shared with all participants in a cloud-based system, discussed across the research team, and enriched by phenomenological insights.
View Article and Find Full Text PDFObstetric Sonar, Media Archaeology, Feminist Critique.
J Med Humanit
January 2025
Pratt Institute, Brooklyn, NY, USA.
The snub-nosed, reclining, and serene image of the fetus is commonplace in cultural representations and analyses of obstetric ultrasound. Yet following the provocation of various feminist scholars, taking the fetal sonogram as the automatic object of concern vis-à-vis ultrasound cedes ground to anti-abortionists, who deploy fetal images to argue that life begins at conception and that the unborn are rights bearing subjects who must be protected. How might feminists escape this analytical trap, where discussions of ultrasonics must always be engaged in the act of debunking? This article orients away from the problem of fetal representation by employing a method which may appear to be wildly unsuitable: media archaeology.
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