AI Article Synopsis
- The text outlines a method for creating α,β-dichlorinated ketones from α,β-dichlorinated Weinreb amides.
- By using nonaqueous HCl for quenching, this approach minimizes side reactions that usually occur during traditional work-up processes.
- Additionally, the method allows the amide to react with different nucleophiles, yielding high amounts of the desired ketones and presenting a unique reactivity for the Weinreb amide.
Article Abstract
An efficient synthesis of α,β-dichlorinated ketones from α,β-dichlorinated Weinreb amides is described. Quenching with nonaqueous HCl avoided side reactions associated with typical work-up procedures. The amide reacted with various nucleophiles to give the corresponding ketones in high yields. A novel reactivity of the Weinreb amide is also discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d1ob01379c | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A new mesoporous Ce-Mn-LDH-based Co-MOF nano-composite for the green synthesis of tetrazoloquinazolines.
Nanoscale Adv
November 2024
Department of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina University Hamedan Iran +98-81-31408025 +98-81-38380922.
Tannic acid (TA), as a plant polyphenol, has many active sites for chelation with metals, so TA-oligomers (TA-Olig) were used for the first time as ligands on the surface of Ce-Mn-LDH to prepare the layered double hydroxide-based metal-organic framework (Ce-Mn-LDH@CPTMS@TA-Olig@Co-MOF = E) nanocomposite. In this regard, a homogeneous water/ethanol solution was prepared by sol-gel method using polyethylene glycol and ammonia solution, and then TA was converted into a set of oligomers in the presence of formaldehyde. In the next step, Ce-Mn-LDH was prepared in a ratio of 1 : 4 of Ce to Mn, modified with 3-chloropropylmethoxysilane, functionalized by TA-Olig, and then cobalt salt was used to prepare E.
View Article and Find Full Text PDFenhances oxidative stress tolerance through rhamnose-dependent mechanisms.
Front Microbiol
December 2024
Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of One Health, School of Life and Health Sciences, Hainan University, Haikou, Hainan, China.
This study probes into the unique metabolic responses of (), a key player in the gut microbiota, when it metabolizes rhamnose rather than typical carbohydrates. Known for its predominant role in the Bacteroidetes phylum, efficiently breaks down poly- and mono-saccharides into beneficial short-chain fatty acids (SCFAs), crucial for both host health and microbial ecology balance. Our research focused on how this bacterium's SCFA production differ when utilizing various monosaccharides, with an emphasis on the oxidative stress responses triggered by rhamnose consumption.
View Article and Find Full Text PDFMaterial stocks of infrastructure, buildings, and machinery are the biophysical basis of production and consumption. They are a crucial lever for resource efficiency and a sustainable circular economy. While material stock research has proliferated over the last years, most studies investigated specific materials or end-uses, usually not embedded into an economy-wide perspective.
View Article and Find Full Text PDFManagement of building materials' stocks and flows is a major opportunity for circularity and de-carbonization. We examine the relationship between material consumption and associated greenhouse gas (GHG) emissions under different scenarios in Israel, a developed country with an already high population density that expects tremendous growth in its housing stock by 2050. We created scenarios of varying housing unit sizes and additional material efficiency practices: fabrication yield, lifetime extension, material substitution, recycling, and their combination, resulting in 18 scenarios.
View Article and Find Full Text PDF[Progress in applications of ambient ionization mass spectrometry for lipids identification].
Se Pu
January 2025
Key Laboratory of Radiopharmaceuticals, Ministry of Education, College of Chemistry, Beijing Normal University, Beijing 100875, China.
Lipids are indispensable components of living organisms and play pivotal roles in cell-membrane fluidity, energy provision, and neurotransmitter transmission and transport. Lipids can act as potential biomarkers of diseases given their abilities to indicate cell-growth status. For example, the lipid-metabolism processes of cancer cells are distinct from those of normal cells owing to their rapid proliferation and adaptation to ever-changing biological environments.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!