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Mikhail 'Misha' Blagosklonny's enduring legacy in geroscience: the hyperfunction theory and the therapeutic potential of rapamycin.
Aging (Albany NY)
January 2025
Geneva College of Longevity Science, Geneva 1204, Switzerland.
The untimely passing of Dr. Mikhail "Misha" Blagosklonny has left a lasting void in geroscience and oncology. This review examines his profound contributions, focusing on his pioneering the Hyperfunction Theory and his advocacy for rapamycin, an mTOR inhibitor, as a therapeutic agent for lifespan extension.
View Article and Find Full Text PDFEpigenetic clocks and programmatic aging.
Ageing Res Rev
November 2024
Genomics of Ageing and Rejuvenation Lab, Institute of Inflammation and Ageing, University of Birmingham, B15 2WB, United Kingdom.
The last decade has seen remarkable progress in the characterization of methylation clocks that can serve as indicators of biological age in humans and many other mammalian species. While the biological processes of aging that underlie these clocks have remained unclear, several clues have pointed to a link to developmental mechanisms. These include the presence in the vicinity of clock CpG sites of genes that specify development, including those of the Hox (homeobox) and polycomb classes.
View Article and Find Full Text PDFConsolidating multiple evolutionary theories of ageing suggests a need for new approaches to study genetic contributions to ageing decline.
Ageing Res Rev
September 2024
Ohio Musculoskeletal and Neurological Institute, Heritage College of Osteopathic Medicine, Athens, OH 45701, United States. Electronic address:
Understanding mechanisms of ageing remains a complex challenge for biogerontologists, but recent adaptations of evolutionary ageing theories offer a compelling lens in which to view both age-related molecular and physiological deterioration. Ageing is commonly associated with progressive declines in biochemical and molecular processes resulting from damage accumulation, yet the role of continued developmental gene activation is less appreciated. Natural selection pressures are at their highest in youthful periods to modify gene expression towards maximising reproductive capacity.
View Article and Find Full Text PDFVocal Tract Discomfort Scale-Brazil (VTDS-BR): Validation Based on Internal Consistency, Reliability, and Accuracy.
J Voice
April 2024
Postgraduate Program in Decision Models and Health, Federal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil; Department of Speech-Language Pathology of the UFPB, João Pessoa, Paraíba, Brazil. Electronic address:
Objective: To validate the Vocal Tract Discomfort Scale for the Brazilian Portuguese (VTDS-BR), based on internal consistency, reliability, and accuracy.
Methods: The participants were 431 adults of both sexes, divided in two groups: dysphonia (DG) and vocally healthy (VHG). We built a digital database with personal, professional information and the item-by-item VTDS-BR responses of the participants.
Prolonged administration of total glucosides of paeony improves intestinal immune imbalance and epithelial barrier damage in collagen-induced arthritis rats based on metabolomics-network pharmacology integrated analysis.
Front Pharmacol
November 2023
School of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
Article Synopsis
- - Rheumatoid arthritis (RA) is an autoimmune disease linked to intestinal immunity issues, which can lead to joint damage, and the study focuses on Total glucosides of paeony (TGP), a treatment used in China for RA, to understand its effects on intestinal health in RA model rats.
- - TGP was found to improve immune function and restore the intestinal epithelial barrier by regulating lymphocyte ratios and increasing the height of villi compared to crypt depth, with effects observed primarily near the intestinal lumen.
- - Metabolomics and network pharmacology analyses revealed that TGP can reverse disrupted intestinal metabolic profiles and identified key biomarkers and targets for its regulatory effects, including ADA, PNP, and TYR, which were validated through pharmac
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