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Mycobacterium welchii Vaccine Granuloma - A Cautionary Tale.
Int J Mycobacteriol
April 2024
Department of Dermatology, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
Background: Mycobacterium welchii (Mycobacterium w) vaccine was one of the many strategies used to both treat and prevent coronavirus disease 2019 (COVID-19) infection. We report the results of a retrospective analysis of 15 cases with vaccine-site granulomas after administration of prophylactic Mycobacterium w vaccine as part of a trial for COVID-19 and our experience in managing those cases.
Methods: This was a retrospective analysis of 15 patients with vaccine-site granulomas who were given the vaccine as a prophylactic measure as part of a trial with informed consent.
Forequarter Amputation for Malignant Tumours: Tale of Sustained Relevance or Telltale Sign of Doom?
Indian J Surg Oncol
March 2024
Department of Surgical Oncology, Dr. B. Borooah Cancer Institute, AK Azad Road, Gopinath Nagar, Guwahati, Assam 781016 India.
Article Synopsis
- Forequarter amputation (FQA) involves the surgical removal of the upper limb and shoulder girdle, conducted over a two-year period at a cancer center in Northeast India, where 7 patients underwent this procedure and 15 patients had limb salvage surgery.
- The study revealed a male-to-female ratio of 3:4, with a median patient age of 32 years, and various histological diagnoses including osteosarcoma and chondrosarcoma, among others.
- Follow-up showed that five patients experienced distant recurrence, mostly within 3 to 8 months, while two patients were disease-free after 17 and 18 months, indicating some
Lower gut bleeding is an alarming sign among caregivers. Determining the etiology is of utmost importance for further management. This is the first study conducted in northernmost India.
View Article and Find Full Text PDFThrombosis and APS: Lessons Learned from Another Black Swan Tale.
Lupus
December 2023
University Center of Excellence on Nephrologic, Rheumatologic and Rare Diseases (ERK-Net, ERN-Reconnect and RITA-ERN Member) with Nephrology and Dialysis Unit and Center of Immuno-Rheumatology and Rare Diseases (CMID), Coordinating Center of the Interregional Network for Rare Diseases of Piedmont and Aosta Valley, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
Article Synopsis
- Antiphospholipid syndrome (APS) is an autoimmune disease that leads to blood clots and can cause issues during pregnancy due to the presence of antiphospholipid antibodies.
- A case study is presented involving a patient who faced recurrent venous thrombosis and skin ulcerations, which did not improve with standard anticoagulant treatment.
- The patient eventually showed significant improvement with immunomodulatory therapy, highlighting the need to consider APS in young patients with unexplained blood clots and the importance of testing for antiphospholipid antibodies.
Disseminated Mucocutaneous Histoplasmosis Diagnosed in the United Kingdom, Presumably as a Result of Recrudescence Decades After Primary Infection Following Immunosuppressive Treatment of Its Mimic, Sarcoidosis: A Multidisciplinary Cautionary Tale.
Am J Dermatopathol
December 2022
Department of Pathology, Western General Hospital and The University of Edinburgh, Edinburgh, United Kingdom.
Histoplasmosis is a dimorphic fungal infection, which is rare outside endemic pockets in North, Central, and South America, Asia, and Africa. Herein, we describe a woman in her 80s living in the Scottish Borders region of the United Kingdom with a recent diagnosis of granulomatous rosacea, who on receiving escalating immunosuppression for suspected sarcoidosis, and long-standing rheumatoid arthritis developed a striking eruption involving her eyelids along with painful ulceration of the oral and nasal mucosa. Histopathologic examination of the skin and mucosal lesions demonstrated granulomatous inflammation with numerous yeast forms of fungal organisms with morphological characteristics of Histoplasma species.
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