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Nanoscale Characterization of Interaction of Nucleosomes with H1 Linker Histone.
Int J Mol Sci
December 2024
Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE 68198-6025, USA.
In eukaryotic nuclei, DNA is wrapped around an octamer of core histones to form nucleosomes. H1 binds to the linker DNA of nucleosome to form the chromatosome, the next structural unit of chromatin. Structural features on individual chromatosomes contribute to chromatin structure, but not fully characterized.
View Article and Find Full Text PDFPinto Bean Pressure Wraps: A Novel Approach to Treating Digital Warts.
Cutis
November 2024
Forefront Dermatology, West Burlington, Iowa.
Identifying an optimal treatment method for verruca vulgaris can be a frustrating challenge for clinicians. We describe the use of a pinto bean pressure wrap to induce ischemic change in digital warts. This novel technique provides a low-cost, low-risk, and nearly pain-free home-based treatment option with response rates similar to those of other commonly employed methods.
View Article and Find Full Text PDFDynamics of Nucleosomes and Chromatin Fibers Revealed by Single-Molecule Measurements.
BMB Rep
January 2025
Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan (44919), Republic of Korea.
The nucleosome is the fundamental structural unit of chromosome fibers. A DNA wraps around a histone octamer to form a nucleosome, while neighboring nucleosomes interact to form higher-order structures and fit gigabase-long DNAs into a small volume of the nucleus. Nucleosomes interrupt the access of transcription factors to a genomic region, and provide regulatory controls of gene expression.
View Article and Find Full Text PDFNucleosome wrapping states encode principles of 3D genome organization.
Nat Commun
January 2025
Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, 518132, China.
Nucleosome is the basic structural unit of the genome. During processes like DNA replication and gene transcription, the conformation of nucleosomes undergoes dynamic changes, including DNA unwrapping and rewrapping, as well as histone disassembly and assembly. However, the wrapping characteristics of nucleosomes across the entire genome, including region-specificity and their correlation with higher-order chromatin organization, remains to be studied.
View Article and Find Full Text PDFResolving the Kinetics of Single-Walled Carbon Nanotube-Polyester Polyurethane Nanoparticle Conjugate Fluorescence Sensors toward Polymer Degrading Enzymes.
Nano Lett
January 2025
Department of Chemical and Biological Engineering, Iowa State University, Ames, Iowa 50011, United States.
Single-walled carbon nanotubes (SWCNTs) are fluorescent materials that have been developed as sensors for measuring the activities of enzymes. However, most sensors to date rely on end-point measurement and empirical functions to correlate enzyme concentrations with fluorescence responses. Less emphasis is put on analyzing time-dependent fluorescence responses and their connections with enzymatic kinetics.
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