The coronavirus-19 (COVD-19) pandemic has resulted in strains on critical care resources throughout the world. Existing and newly developed guidelines for the allocation of scarce resources, including ventilators, frequently use the Sequential Organ Failure Assessment (SOFA) score for prognostic determination. This article will outline how SOFA scores were neither designed nor tested for this purpose and why guidelines based upon SOFA score groupings do not conform to ethical principles and community values.
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Increased circulatory Krebs cycle metabolites in sepsis is associated with increased interleukin-6 release and worse survival.
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Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
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Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 1470 Madison Avenue, New York, NY, 10029, USA.
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