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This study aims to investigate the effect of promethazine (PMZ) on hippocampal neuronal injury through network pharmacology and in vivo experiments. Network pharmacology: The intersection genes of PMZ and Alzheimer Disease (AD) were obtained, and the core genes of PMZ in AD were screened. The intersection genes were enriched by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses.
View Article and Find Full Text PDFSAHA potentiates the activity of repurposed drug promethazine loaded PLGA nanoparticles in triple-negative breast cancer cells.
Nanotechnology
August 2024
Centre for Nanotechnology, Indian Institute of Technology Guwahati, Guwahati 781039, Assam, India.
Article Synopsis
- Triple-negative breast cancer (TNBC) is highly aggressive due to a lack of targetable bioreceptors and features like epithelial to mesenchymal transition (EMT), which enhances its metastatic abilities.
- Researchers developed a combination therapy using promethazine hydrochloride-loaded PLGA nanoparticles, which showed efficient delivery and anti-cancer effects in experimental studies, particularly when used alongside the histone deacetylase inhibitor SAHA.
- The study found that SAHA not only increased the effectiveness of the drug-loaded nanoparticles but also altered EMT dynamics, promoting a shift towards less aggressive cancer cell characteristics, thus highlighting the potential of combining nanotechnology with repurposed drugs for treating TNBC.
Unleashing the Potential of β -cyclodextrin Inclusion Complexes in Bitter Taste Abatement: Development, Optimization and Evaluation of Taste Masked Anti-emetic Chewing Gum of Promethazine Hydrochloride.
AAPS PharmSciTech
July 2024
Department of Pharmaceutical Sciences, M.D. University, Rohtak, 124001, India.
Motion sickness also known as kinetosis is a condition in which there exists a disagreement between visually perceived movement and the vestibular system's sense of movement. Nausea, vomiting, dizziness, fatigue, and headache are the most common symptoms of motion sickness. This study mainly focuses on the taste masking of Promethazine Hydrochloride (PMZ) by inclusion complexation method, its formulation development in the chewing gum form by using directly compressible gum base HIG® and its quality and performance testing.
View Article and Find Full Text PDFRepurposing promethazine hydrochloride to inhibit biofilm formation against Burkholderia thailandensis.
Med Microbiol Immunol
July 2024
Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China.
Melioidosis is a severe infectious disease caused by Burkholderia pseudomallei, an intracellular pathogen with a high mortality rate and significant antibiotic resistance. The high mortality rate and resistance to antibiotics have drawn considerable attention from researchers studying melioidosis. This study evaluated the effects of various concentrations (75, 50, and 25 µg/mL) of promethazine hydrochloride (PTZ), a potent antihistamine, on biofilm formation and lipase activity after 24 h of exposure to B.
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