Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.2337/dc21-1235 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Body Composition in Adults Born at Very Low Birthweight-A Sibling Study.
Paediatr Perinat Epidemiol
January 2025
Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Background: Individuals born preterm at very low birthweight (VLBW, < 1500 g) tend to attain a smaller adult body size compared with term-born peers but less is known regarding specific body composition characteristics.
Objectives: We aimed to assess whether adults born at VLBW have less beneficial body composition characteristics, potentially mediating the association between VLBW birth and cardiometabolic disease. Sibling controls were used to account for the potential influence of shared genetic and/or lifestyle factors.
Fat Distribution and Urolithiasis Risk Parameters in Uric Acid Stone Formers and Patients with Type 2 Diabetes Mellitus.
Clin J Am Soc Nephrol
January 2025
Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas.
Key Points: Under a controlled diet, uric acid stone formers (UASFs) and diabetic patients have higher endogenous net acid production. Under a controlled diet, UASFs have lower ammonium-to-net acid excretion ratio. Body fat inversely correlates with urine buffer capacity in normal individuals, but this relationship is lost in diabetic patients and UASFs.
View Article and Find Full Text PDFThe Role of DLK1 Deficiency in Central Precocious Puberty and Association with Metabolic Dysregulation.
Horm Res Paediatr
October 2024
Centre for Endocrinology, William Harvey Research Institute, Queen Mary University of London, London, UK.
Article Synopsis
- Precocious puberty occurs when secondary sexual traits appear before age 8 in girls and 9 in boys, with central precocious puberty (CPP) being a rare type linked to early hormonal activation.
- A new case of an 8-year-old girl showed a specific genetic change in the DLK1 gene, leading to advanced puberty and related health issues like obesity and insulin problems.
- The findings emphasize the need for ongoing health monitoring in children with DLK1 mutations, highlighting a trend of metabolic issues such as obesity and irregular cholesterol levels in affected individuals.
Pathogenesis and Surgical Treatment of Congenitally Corrected Transposition of the Great Arteries (ccTGA): Part III.
J Clin Med
September 2024
Department of Clinical Physiology, Faculty of Medicine, Medical University of Lodz, Mazowiecka 6/8, 92-215 Lodz, Poland.
Congenitally corrected transposition of the great arteries (ccTGA) is an infrequent and complex congenital malformation, which accounts for approximately 0.5% of all congenital heart defects. This defect is characterized by both atrioventricular and ventriculoarterial discordance, with the right atrium connected to the morphological left ventricle (LV), ejecting blood into the pulmonary artery, while the left atrium is connected to the morphological right ventricle (RV), ejecting blood into the aorta.
View Article and Find Full Text PDFPlasma proteomic signatures for type 2 diabetes mellitus and related traits in the UK Biobank cohort.
medRxiv
September 2024
Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Article Synopsis
- The study evaluates the potential of plasma proteins to predict the risk of type 2 diabetes mellitus (T2DM) and related traits using data from UK Biobank participants.
- Different analysis methods, like LASSO regression, were employed to compare the effectiveness of proteomic data against traditional clinical and genetic data for predicting traits like truncal fat and fitness levels.
- Results showed that integrating proteomic signatures enhanced prediction accuracy for T2DM and other traits beyond existing clinical risk scores, indicating their value in disease prognostics.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!