[Figure: see text].
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http://dx.doi.org/10.1161/CIRCEP.121.010013 | DOI Listing |
Geroscience
December 2024
Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, 27701, USA.
Extracellular vesicles (EVs) play crucial roles in aging. In this National Institutes on Aging-funded study, we sought to identify circulating extracellular vesicle (EV) biomarkers indicative of longevity. The plasma EV proteome of 48 older adults (mean age 77.
View Article and Find Full Text PDFJ Mol Cell Cardiol Plus
December 2024
Department of Biological Sciences, Mississippi State University, Starkville, MS 39762, USA.
Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic arrhythmic syndrome caused by mutations in the calcium (Ca) release channel ryanodine receptor (RyR2) and its accessory proteins. These mutations make the channel leaky, resulting in Ca-dependent arrhythmias. Besides arrhythmias, CPVT hearts typically lack structural cardiac remodeling, a characteristic often observed in other cardiac conditions (heart failure, prediabetes) also marked by RyR2 leak.
View Article and Find Full Text PDFSci Rep
December 2024
Department of Pediatrics, International University of Health and Welfare, Tokyo, Japan.
Dilated cardiomyopathy (DCM) is a progressive myocardial disorder characterized by impaired cardiac contraction and ventricular dilation. However, some patients with DCM improve when experiencing left ventricular reverse remodeling (LVRR). Currently, the detailed association between genotypes and clinical outcomes, including LVRR, particularly among children, remains uncertain.
View Article and Find Full Text PDFCancer Med
December 2024
Research Center of Cancer Diagnosis and Therapy, Department of Oncology, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Background: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer. Previous studies have found that fibroblast growth factor receptor 4 (FGFR4) plays a crucial role in tumor development and metastasis. However, the potential role and underlying mechanisms of FGFR4 in the progression of TNBC remain unclear.
View Article and Find Full Text PDFCochrane Database Syst Rev
December 2024
Department of Paediatric Neurology, University of Cape Town, Cape Town, South Africa.
This is a protocol for a Cochrane Review (intervention). The objectives are as follows: Primary objective To analyse the benefits and harms of pharmacological or other interventions (e.g.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!