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Protective effects of phosphocreatine against Doxorubicin-Induced cardiotoxicity through mitochondrial function enhancement and apoptosis suppression via AMPK/PGC-1α signaling pathway.
Int Immunopharmacol
January 2025
Collage of Pharmacology, Dalian Medical University, 9 West Section, South Road of Lushun, 116044 Dalian, China. Electronic address:
Doxorubicin (DOX), a potent chemotherapy drug, is limited by its cardiotoxic effects, which can lead to heart damage. This study explores the cardioprotective potential of Phosphocreatine (PCr) in vitro and in vivo models, focusing on its impact on the AMPK and PGC-1α pathways, apoptosis reduction, and mitochondrial function preservation. Advanced methodologies, including high-resolution respirometry (HRR), were employed to assess mitochondrial bioenergetics, AMPK activity, and apoptotic rates in cardiomyocytes.
View Article and Find Full Text PDFDiagnostic and therapeutic optical imaging in cardiovascular diseases.
iScience
November 2024
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Article Synopsis
- * Optical imaging technology is emerging as a promising non-invasive alternative that offers high-resolution and real-time monitoring capabilities for CVD diagnosis and research.
- * The review highlights various optical techniques, their applications in conditions like atherosclerosis and myocardial infarction, as well as challenges in deep-tissue imaging; it advocates for advancements in these technologies to improve diagnostic precision and treatment options for CVD.
[Intrinsic steady-state pattern of mouse cardiac electrophysiology: analysis using a characterized quantitative electrocardiogram strategy].
Nan Fang Yi Ke Da Xue Xue Bao
October 2024
School of Medicine, South China University of Technology, Guangzhou 510006, China.
Article Synopsis
- The study aimed to analyze the steady-state electrophysiological properties of the mouse heart under normal physiological conditions using high-resolution techniques.
- Twenty-two young adult C57BL/6 mice (1:1 male-to-female ratio) were used to record ECG waveforms, and various parameters were quantified through specialized software, revealing gender differences in cardiac characteristics.
- The findings indicated significant variations between male and female hearts, including differences in wave amplitudes and correlations, ultimately suggesting a distinct intrinsic correlation network based on sex.
Origin of ventricular fibrillation triggers in a model of localized repolarization heterogeneity.
Heart Rhythm
October 2024
Univ. Bordeaux, INSERM, CRCTB, U 1045, IHU Liryc, Bordeaux, France.
Article Synopsis
- Heterogeneities in ventricular repolarization play a key role in causing ventricular fibrillation (VF), but the specific triggers and their origins are not well understood.
- The study aimed to investigate how VF is initiated in a model of repolarization heterogeneity and to pinpoint where these triggers arise.
- Using isolated porcine right ventricles, researchers induced VF after creating a repolarization gradient, discovering that triggers consistently originated from the border zone between altered and normal repolarization areas.
Novel Insights into Non-Invasive Diagnostic Techniques for Cardiac Amyloidosis: A Critical Review.
Diagnostics (Basel)
October 2024
Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Polyclinic University Hospital, 70124 Bari, Italy.
Cardiac amyloidosis (CA) is a cardiac storage disease caused by the progressive extracellular deposition of misfolded proteins in the myocardium. Despite the increasing interest in this pathology, it remains an underdiagnosed condition. Non-invasive diagnostic techniques play a central role in the suspicion and detection of CA, also thanks to the continuous scientific and technological advances in these tools.
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