Purpose: The purpose of this study was to evaluate the best phantom for calculating the becquerel calibration factor (BCF) and correction method to obtain the improvement of standardized uptake value (SUV) accuracy in both single photon emission computed tomography (SPECT) and SPECT/CT.
Method: A SPECT/CT scanner was used in this study. BCFs were calculated using four phantoms with different cross sections including National Electrical Manufacturers Association International Electrotechnical Commission body phantom (NEMA IEC body phantom) filled with TcO, and five correction methods were used for reconstruction. SUVs were calculated by the NEMA IEC body phantom and pediatric phantom in house with these BCFs. We then measured SUV in the background region of the NEMA IEC body phantom, SUV and SUV of the 37-mm-diameter sphere.
Results: In the SPECT scanner, SUV and SUV measured 1.04 and 4.02, respectively, in the case of BCF calculation and SUV measurement using NEMA IEC body phantoms without corrections. In the SPECT/CT scanner, SUV with CT attenuation correction (AC) was in agreement with the theoretical values using each phantom. SUV showed the same trend.
Conclusion: In the SPECT scanner, it is possible to obtain a highly accurate SUV by using a phantom that matches the size of the subject for BCF calculation and without correction. In the SPECT/CT scanner, highly accurate SUVs can be obtained by using CT-based attenuation correction, and these values do not depend on the size of the BCF calculation phantom.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.6009/jjrt.2021_JSRT_77.9.921 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Design of a Cost-Effective Ultrasound Force Sensor and Force Control System for Robotic Extra-Body Ultrasound Imaging.
Sensors (Basel)
January 2025
School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.
Ultrasound imaging is widely valued for its safety, non-invasiveness, and real-time capabilities but is often limited by operator variability, affecting image quality and reproducibility. Robot-assisted ultrasound may provide a solution by delivering more consistent, precise, and faster scans, potentially reducing human error and healthcare costs. Effective force control is crucial in robotic ultrasound scanning to ensure consistent image quality and patient safety.
View Article and Find Full Text PDFRealistic total-body J-PET geometry optimization: Monte Carlo study.
Med Phys
January 2025
Faculty of Physics, Astronomy and Applied Computer Science, Jagiellonian University, Kraków, Poland.
Background: Total-body (TB) Positron Emission Tomography (PET) is one of the most promising medical diagnostics modalities, opening new perspectives for personalized medicine, low-dose imaging, multi-organ dynamic imaging or kinetic modeling. The high sensitivity provided by total-body technology can be advantageous for novel tomography methods like positronium imaging, demanding the registration of triple coincidences. Currently, state-of-the-art PET scanners use inorganic scintillators.
View Article and Find Full Text PDFEffects of different combinations of noise index and preset adaptive statistical iterative reconstruction Veo on the accuracy and image quality of bone mineral density measurements using fast kilovolt-switching dual-energy computed tomography: a phantom study.
Quant Imaging Med Surg
January 2025
Department of Imaging Medicine and Nuclear Medicine, Shandong Second Medical University, Weifang, China.
Background: Rapid kilovolt (kV)-switching dual-energy computed tomography (DECT) has been increasingly applied to the measurement of lumbar spine bone mineral density (BMD) in humans and animal models. The objective of this study was to investigate the optimal parameters for the measurement of vertebral BMD. The BMD of the spinal model was measured by means of DECT in combination with different noise index (NI) and preset adaptive statistical iterative reconstruction Veo (ASiR-V) levels.
View Article and Find Full Text PDFMeasurement and Analysis of Optical Transmission Characteristics of the Human Skull.
J Biophotonics
January 2025
Department of Emergency, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China.
The brain, as a vital part of central nervous system, receives approximately 25% of body's blood supply, making accurate monitoring of cerebral blood flow essential. While fNIRS is widely used for measuring brain physiology, complex tissue structure affects light intensity, spot size, and detection accuracy. Many studies rely on simulations with limited experimental validation.
View Article and Find Full Text PDFA Method for Validating PET and SPECT Cameras for Quantitative Clinical Imaging Trials Using Novel Radionuclides.
J Nucl Med
January 2025
Department of Nuclear Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia.
Our aim is to report methodology that has been developed to calibrate and verify PET and SPECT quantitative image accuracy and quality assurance for use with nonstandard radionuclides, especially with longer half-lives, in clinical imaging trials. Procedures have been developed for quantitative PET and SPECT image calibration for use in clinical trials. The protocol uses a 3-step approach: check quantitative accuracy with a previously calibrated radionuclide in a simple geometry, check the novel trial radionuclide in the same geometry, and check the novel radionuclide in a more challenging, complex geometry (the National Electrical Manufacturers Association [NEMA] NU-2 International Electrotechnical Commission [IEC] image-quality phantom).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!