AI Article Synopsis
- COVID-19 has led to serious health issues and deaths globally, highlighting the need for a better understanding of its effects on the body.
- A study conducted on four patients who died from COVID-19 found significant organ damage through postmortem biopsies, mainly in the lungs but also in the heart, liver, spleen, and kidneys.
- The findings from this research, involving detailed examinations by six pathologists, contribute valuable insights into the histopathological impacts of the virus and can help improve understanding of its long-term effects.
Article Abstract
Coronavirus disease 2019 (COVID-19) has spread worldwide, resulting in significant morbidity and mortality. Histopathological findings are essential in understanding its pathogenesis and we present our findings from postmortem core needle biopsies in an attempt to share information that may shed some light on this severe pandemic. Different organ samples from four patients with PCR-confirmed COVID-19 at the Infanta Sofía Hospital (Madrid) were studied during the months of April and May, 2020 by six pathologists using routine stains, histochemistry and immunohistochemistry. Results were compared with other reported cases. All patients had a clinical diagnosis of pneumonia and biopsies revealed lung damage in the majority. Heart, liver, spleen and kidney were also studied and abnormalities were found in all cases and are extensively described. The histopathology of organs affected by COVID-19 is vital to the understanding of this disease and its sequelae.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7534875 | PMC |
| http://dx.doi.org/10.1016/j.patol.2020.09.003 | DOI Listing |
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