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The glycosylation status of MHC class I molecules impacts their interactions with TAPBPR. | LitMetric

The glycosylation status of MHC class I molecules impacts their interactions with TAPBPR.

Mol Immunol

Department of Pathology, University of Cambridge, Cambridge, CB2 1QP, UK. Electronic address:

Published: November 2021

AI Article Synopsis

Article Abstract

Glycosylation plays a crucial role in the folding, structure, quality control and trafficking of glycoproteins. Here, we explored whether the glycosylation status of MHC class I (MHC-I) molecules impacts their affinity for the peptide editor, TAPBPR. We demonstrate that the interaction between TAPBPR and MHC-I is stronger when MHC-I lacks a glycan. Subsequently, TAPBPR can dissociate peptides, even those of high affinity, more easily from non-glycosylated MHC-I compared to their glycosylated counterparts. In addition, TAPBPR is more resistant to peptide-mediated allosteric release from non-glycosylated MHC-I compared to species with a glycan attached. Consequently, we find the glycosylation status of HLA-A*68:02, -A*02:01 and -B*27:05 influences their ability to undergo TAPBPR-mediated peptide exchange. The discovery that the glycan attached to MHC-I significantly influences the affinity of their interactions with TAPBPR has important implications, on both an experimental level and in a biological context.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8524320PMC
http://dx.doi.org/10.1016/j.molimm.2021.09.007DOI Listing

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