Effect of hyaluronic acid and laminin in coronary heart disease patients complicated with myocardial infarction.

Objective: To investigate the expression and significance of serum hyaluronic acid (HA) and laminin (LN) in patients with coronary heart disease (CHD) complicated with myocardial infarction (MI).

Methods: From July 2016 to July 2019, 280 CHD patients without MI admitted to the department of cardiology in our hospital were enrolled into a CHD group, and another 280 CHD patients complicated with MI into an infarction group. The expressions of serum LN and HA were compared between the two groups to analyze its correlation with blood lipid and blood glucose levels, and the results of serum protein electrophoresis (SPE) as well as the levels of mean platelet volume (MPV), high-sensitivity C-reactive protein (hs-CRP), cardiac troponin I (cTnI) and left ventricular ejection fraction (LVEF) were compared between the two groups.

Result: The infarction group showed significantly higher expressions of serum LN and HA than the CHD group (P < 0.01), and their expressions increased with the elevation of the number of lesions (P < 0.05). Compared with patients with combined anterior and inferior wall infarction, LN and HA showed remarkably lower levels in patients with anterior wall infarction or inferior wall infarction (P < 0.05). Additionally, the infarction group obtained higher expressions of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), and fasting plasma glucose (FPG), but a lower level of high-density lipoprotein cholesterol (HDL-C) than the CHD group (all P < 0.01), which demonstrated that LN and HA were positively correlated with TC, TG, hs-CRP, FPG, and LDL-C (all P < 0.05), but negatively correlated with HDL-C (P < 0.05). Moreover, the infarction group presented a notably higher level of β1-globulin than the CHD group, and the increase in β1-globulin level may have increased the readmission rate and mortality of patients with CHD complicated with MI. MPV was negatively correlated with LVEF (P < 0.05), but positively correlated with the serum hs-CRP and cTnI levels (both P < 0.05).

Conclusion: The expressions of serum HA and LN in patients with CHD complicated with MI witnessed an elevation, which indicated a positive correlation between their expression and the levels of blood lipid and blood glucose. A higher readmission rate and mortality of patients with CHD complicated with MI may be triggered by the elevation of β1-globulin, and MPV can be used as an objective index to evaluate the condition of patients with MI.