Objective: To explore the characteristics of optimal ablation site and its surrounding tissue in terms of unipolar and bipolar voltage mapping in idiopathic arrythmias from right ventricular outflow tract (RVOT) to understand if there is any difference between the two arrhythmias in matrix.
Method: A total of 40 patients with idiopathic arrhythmias originated from RVOT (28 PVCs/12 VT) were enrolled in the study group. The control group consisted of five patients with supraventricular tachycardia (SVT). Before ablation, the CARTO system was applied to establish a detailed three-dimensional electroanatomic voltage map (EVM) of RVOT during the sinus rhythm.
Results: A band-like LVA of similar size was observed under the pulmonary valve on not only the bipolar map, but also unipolar map, for every patient. Both unipolar and bipolar voltage values in areas within 5 mm were significantly different from those in other areas above ablation targets, whereas similar differences were observed only in unipolar voltage values below the optimal ablation site for either of the two arrhythmias. Significant difference was present between VT group and VPCs group in voltage values for every area including target site. In terms of the overall LVA areas and the scar areas displayed on the unipolar and bipolar voltage maps, there was a significant difference between the unipolar value and bipolar value for the LVA areas and the scar areas in the VT or PVC group (<0.05).
Conclusions: There was focal micro-scarring around the optimal ablation site. The ectopic focus is probably located in mid- or epi-myocardium. The distributions of majority of optimal ablation sites were regular especially at the noteworthy border of the band-like LVA on bipolar voltage map, or in the band-like LVA on unipolar voltage map.
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Indian Pacing Electrophysiol J
January 2025
Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH, USA. Electronic address:
JACC Clin Electrophysiol
January 2025
Department of Cardiology, Westmead Hospital, Sydney, New South Wales, Australia; Westmead Applied Research Centre, University of Sydney, Sydney, New South Wales, Australia. Electronic address:
Background: Accurate electroanatomic mapping is critical for identifying scar and the long-term success of ventricular tachycardia ablation.
Objectives: This study sought to determine the accuracy of multielectrode mapping (MEM) catheters to identify scar on cardiac magnetic resonance (CMR) and histopathology.
Methods: In an ovine model of myocardial infarction, we examined the effect of electrode size, spacing, and mapping rhythm on scar identification compared to CMR and histopathology using 5 multielectrode mapping catheters.
Mol Psychiatry
January 2025
Early Psychosis: Interventions and Clinical-Detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Modelling the prodrome to severe mental disorders (SMD), including unipolar mood disorders (UMD), bipolar mood disorders (BMD) and psychotic disorders (PSY), should consider both the evolution and interactions of symptoms and substance use (prodromal features) over time. Temporal network analysis can detect causal dependence between and within prodromal features by representing prodromal features as nodes, with their connections (edges) indicating the likelihood of one feature preceding the other. In SMD, node centrality could reveal insights into important prodromal features and potential intervention targets.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China.
Crystalline organic semiconductors, recognized for their highly ordered structures and high carrier mobility, have emerged as a focal point in the field of high-performance optoelectronic devices. Nevertheless, the intrinsic unipolar properties, characterized by imbalanced hole and electron transport capabilities, have continuously represented a significant challenge in the advancement of high-performance crystalline thin-film organic light-emitting diodes (C-OLEDs). Here, a bipolar solid-solution thin film with a maintained crystal structure has been fabricated using 2-(4-(9H-carbazol-9-yl)phenyl)-1(3,5-difluorophenyl)-1H-phenanthro [9,10-d]imidazole (2FPPICz) and 4-(1-(3,5-difluorophenyl)-1H-imidazo[4,5-][1,10]phenanthrolin-2-yl)-N,N-diphenylaniline (2Fn) via a weak epitaxial growth (WEG) process, exhibiting nearly equivalent hole and electron mobilities (10-10 cm V s).
View Article and Find Full Text PDFJ Interv Card Electrophysiol
January 2025
Department of Cardiovascular Medicine, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsugagun, Tochigi, 321-0293, Japan.
Background: The conventional mapping approach for the atrioventricular accessory pathway (AP) involves point-by-point mapping to identify the connection sites of the AP to the atria or ventricle and accurate interpretation of local electrograms. Omnipolar mapping technology (OMT) explains how vector and wave speed are produced by using both unipolar and bipolar signals to obtain omnipolar signals, directions, and conduction velocity. The aim of this study is to verify the effectiveness of OMT for catheter ablation of AP.
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