YTHDF2 is responsible for maintaining the dynamic N-methyladenosine (mA) modification balance and influences a variety of cancers. We tested whether gene rs3738067 A>G polymorphism is related to Wilms tumor by genotyping samples of Chinese children (450 cases and 1317 controls). However, the rs3738067 A>G polymorphism showed no statistical significance with Wilms tumor susceptibility. Stratification analysis also revealed that there was no remarkable association of rs3738067 variant AG/GG genotype with Wilms tumor risk in every subgroup (age, gender, and clinical stages). In all, the results indicated gene rs3738067 A>G polymorphism could not alter Wilms tumor risk significantly.
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| http://dx.doi.org/10.7150/jca.62154 | DOI Listing |
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