In recent years, there has been a growing interest in the use of reference conceptual models to capture information about complex and sensitive business domains (e.g., finance, healthcare, space). These models play a fundamental role in different types of critical semantic interoperability tasks. Therefore, domain experts must be able to understand and reason with their content. In other words, these models need to be . This paper contributes to this goal by proposing a model clustering technique that leverages on the rich semantics of ontology-driven conceptual models (ODCM). In particular, we propose a formal notion of to guide the automated clusterization (or modular breakdown) of conceptual models. Such Relational Contexts capture all the information needed for understanding entities "qua players of roles" in the scope of an objectified (reified) relationship (relator). The paper also presents computational support for automating the identification of Relational Contexts and this modular breakdown procedure. Finally, we report the results of an empirical study assessing the cognitive effectiveness of this approach.
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http://dx.doi.org/10.1007/s10270-021-00919-5 | DOI Listing |
Clin Pharmacokinet
January 2025
College of Pharmacy, Kyungsung University, 309, Suyeong-ro, Nam-gu, Busan, 48434, Republic of Korea.
Background And Objective: Telmisartan exhibits significant pharmacokinetic (PK) variability, but it remains unclear whether its PK profile is altered in hypertensive patients. This study aimed to characterize telmisartan PKs by conducting a meta-analysis and developing a pooled population PK model based on data from healthy subjects and hypertensive patients.
Methods: Relevant literature was identified by a systematic approach.
Chirurgie (Heidelb)
January 2025
Klinik für Mund‑, Kiefer- und Plastische Gesichtschirurgie, Zentrum für Zentrum für Lippen-Kiefer-Gaumenspalten und seltene oro-kranio-faziale Fehlbildungen, Universitätsmedizin Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt am Main, Deutschland.
Background: Cleft lip and palate is the most frequent malformation in humans that requires surgical correction but is not primarily life-threatening. That is why in many economically not very well developed countries, special surgical care, such as for cleft lip and palate, is not guaranteed at all or is not sufficiently guaranteed, so that numerous aid organizations have been founded for over 50 years to provide help by organizing surgical aid missions. Even if this help seems primarily ethically harmless and very laudable, the lack of rules and instructions unfortunately regularly leads to the fact that legal, ethical and even medical treatment standards are often not observed to the detriment of the affected children.
View Article and Find Full Text PDFFront Psychol
December 2024
Department of Biological Psychology and Affective Science, Faculty of Human Sciences, University of Potsdam, Potsdam, Germany.
Introduction: It has long been known that highly arousing emotional single items are better recollected than low arousing neutral items. Despite the robustness of this memory advantage, emotional arousing events may not always promote the retrieval of source details (i.e.
View Article and Find Full Text PDFJ Soc Cardiovasc Angiogr Interv
December 2024
Harvard Medical School, Boston, Massachusetts.
The clinical presentation and epidemiology of infective endocarditis (IE) have evolved over time. While the cornerstones of IE treatment remain antimicrobial therapy and surgery, percutaneous mechanical aspiration (PMA) has emerged as an option for carefully selected patients as a complementary modality, based on retrospective data, case series, and expert experience. In this comprehensive review, we summarize the proceedings from an inaugural summit dedicated to the discussion of PMA in the global management of IE, consisting of experts across multiple disciplines from diverse geographic regions and care environments.
View Article and Find Full Text PDFCan Med Educ J
December 2024
Department of Medical Education, University of Illinois College of Medicine, Illinois, USA.
Background: Cognitive integration occurs when trainees make conceptual connections between relevant knowledges and is known to improve learning. While several experimental studies have demonstrated how text and audio-visual instruction can be designed to enhance cognitive integration, clinical skills training in real-world contexts may require alternative educational strategies. Introducing three-dimensional (3D) printed models during clinical skills instruction may offer unique learning opportunities to support cognitive integration.
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