Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445735 | PMC |
| http://dx.doi.org/10.1016/S0140-6736(21)02099-7 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Enhanced Staphylococcus aureus protection by uncoupling of the α-toxin-ADAM10 interaction during murine neonatal vaccination.
Nat Commun
October 2024
Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Staphylococcus aureus remains a leading global cause of bacterial infection-associated mortality and has eluded prior vaccine development efforts. S. aureus α-toxin (Hla) is an essential virulence factor in disease, impairing the T cell response to infection.
View Article and Find Full Text PDFOpposing effects of pre-existing antibody and memory T cell help on the dynamics of recall germinal centers.
Immunity
July 2024
Laboratory of Lymphocyte Dynamics, The Rockefeller University, New York, NY, USA. Electronic address:
Re-exposure to an antigen generates abundant antibody responses and drives the formation of secondary germinal centers (GCs). Recall GCs in mice consist almost entirely of naïve B cells, whereas recall antibodies derive overwhelmingly from memory B cells. Here, we examine this division between cellular and serum compartments.
View Article and Find Full Text PDFEvaluating the possible genotoxicity of nanoaluminum incorporated in human vaccines and the potential protective role of nanocurcumin: an study.
Toxicol Mech Methods
September 2024
Department of Forensic Medicine and Clinical Toxicology, Cairo University, Cairo, Egypt.
For nearly 90 years, aluminum (Al) salts have been utilized as vaccination adjuvants. Nevertheless, there is a risk of adverse effects associated with the amount of nanoaluminum used in various national pediatric immunization regimens. This study aimed to investigate the possible genotoxic effects of nanoaluminum incorporated in human vaccines on the brains of newborn albino rats and whether nanocurcumin has a potential protective effect against this toxicity.
View Article and Find Full Text PDFQuorum-sensing system of primes gene expression for protection from lethal oxidative stress.
Elife
April 2024
Department of Medicine, Division of Infectious Diseases, NYU Grossman School of Medicine, New York, United States.
The quorum-sensing system links metabolism to virulence, in part by increasing bacterial survival during exposure to lethal concentrations of HO, a crucial host defense against . We now report that protection by surprisingly extends beyond post-exponential growth to the exit from stationary phase when the system is no longer turned on. Thus, can be considered a constitutive protective factor.
View Article and Find Full Text PDFInnate immune activation restricts priming and protective efficacy of the radiation-attenuated PfSPZ malaria vaccine.
JCI Insight
April 2024
Division of Infectious Diseases, Department of Medicine.
A systems analysis was conducted to determine the potential molecular mechanisms underlying differential immunogenicity and protective efficacy results of a clinical trial of the radiation-attenuated whole-sporozoite PfSPZ vaccine in African infants. Innate immune activation and myeloid signatures at prevaccination baseline correlated with protection from P. falciparum parasitemia in placebo controls.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!