The association between homocysteine and risk of multiple sclerosis (MS) remains unclear. We implemented a two-sample Mendelian randomization (MR) analysis to comprehensively investigate the causal relationships between circulating homocysteine, vitamin B12 (VitB12), and folate levels and MS with data from large-scale genome-wide association studies. MR results demonstrated an inverse association between genetically predicted higher circulating homocysteine levels (per 1 standard deviation (SD) increase) and risk of MS (OR 0.78, 95% CI 0.64-0.94, p = 0.0106). No significant causal relationships between genetically determined higher VitB12 and folate levels and MS were observed. Further studies are warranted to elucidate the potential mechanisms.
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| http://dx.doi.org/10.1016/j.msard.2021.103255 | DOI Listing |
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