Freshwater planarians can be useful for the evaluation of contaminant stress on behavioral endpoints. In this work, we studied the sensitivity of the freshwater planarian Girardia tigrina in response to two model stressors (Hg and NaCl) by evaluating mortality, feeding rate and locomotion. A simple feeding assay with G. tigrina was devised, and an automated tracking system was used to evaluate locomotion. The estimated 96 h LCs were 176.8 μg L of Hg and 6.79 g L of NaCl. Acute effects of Hg also included the disintegration of tissues, and loss of pigmentation. Acute effects of NaCl included motionlessness and rupture of the tegument. Hg and NaCl sub-lethal exposures caused feeding inhibition and locomotion impairment. This study demonstrates the usefulness of planarians for ecotoxicological research and that sensitive behavioral endpoints can evaluate the sub-lethal impacts of stressors to freshwater invertebrates.
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http://dx.doi.org/10.1016/j.etap.2021.103747 | DOI Listing |
Background: The Wound Care Collaborative Community (WCCC) assesses shortcomings and unmet needs in wound care by partnering with key stakeholders, such as the National Institutes of Health, the US Food and Drug Administration (FDA), industry leaders, and expert health care providers and researchers, to advance the study of wound healing. Through this work, the WCCC has identified a few key barriers to innovation in wound care. The WCCC aims to accelerate the development of science-based, patient-centered solutions and address public policy challenges related to ensuring patients receive early access to innovative treatment options.
View Article and Find Full Text PDFJ Vis
January 2025
Neuroscience Program, University of Western Ontario, London, Ontario, Canada.
Human performance in perceptual and visuomotor tasks is enhanced when stimulus motion follows the laws of gravitational physics, including acceleration consistent with Earth's gravity, g. Here we used a manual interception task in virtual reality to investigate the effects of trajectory shape and orientation on interception timing and accuracy. Participants punched to intercept a ball moving along one of four trajectories that varied in shape (parabola or tent) and orientation (upright or inverted).
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Alzheimer Center Amsterdam, Neurology, Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc, Amsterdam, Netherlands.
Background: There is a strong link between tau and progression of Alzheimer's disease (AD), necessitating an understanding of tau spreading mechanisms. Prior research, predominantly in typical AD, suggested that tau propagates from epicenters (regions with earliest tau) to functionally connected regions. However, given the constrained spatial heterogeneity of tau in typical AD, validating this connectivity-based tau spreading model in AD variants with distinct tau deposition patterns is crucial.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Background: Amnestic mild cognitive impairment and Alzheimer's disease (aAD) exhibit degeneration of white matter (WM) tracts preceding overt cognitive decline. However, WM changes in non-amnestic AD (naAD) are understudied. We hypothesized patterns of WM degeneration would differ between aAD and naAD.
View Article and Find Full Text PDFBackground: Older adults with mild cognitive impairment (MCI) are known to have declines in cognition greater than that expected for an individual's age and education level but does not significantly interfere with daily functioning. Memory impairments during the early stages of MCI may predict conversion to Alzheimer's disease (AD). This impairment can be especially prominent in associative memory - the ability to learn and remember the relationship between two unrelated items.
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