There has been a fundamental failure to translate preclinically supported research into clinically efficacious treatments for psychiatric disorders. One of the greatest impediments toward improving this species gap has been the difficulty of identifying translatable neurophysiological signals that are related to specific behavioral constructs. Here, we present evidence from three paradigms that were completed by humans and mice using analogous procedures, with each task eliciting candidate a priori defined electrophysiological signals underlying effortful motivation, reinforcement learning, and cognitive control. The effortful motivation was assessed using a progressive ratio breakpoint task, yielding a similar decrease in alpha-band activity over time in both species. Reinforcement learning was assessed via feedback in a probabilistic learning task with delta power significantly modulated by reward surprise in both species. Additionally, cognitive control was assessed in the five-choice continuous performance task, yielding response-locked theta power seen across species, and modulated by difficulty in humans. Together, these successes, and also the teachings from these failures, provide a roadmap towards the use of electrophysiology as a method for translating findings from the preclinical assays to the clinical settings.
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http://dx.doi.org/10.1038/s41398-021-01562-w | DOI Listing |
Psychol Res
January 2025
School of Psychology, Shenzhen University, Shenzhen, China.
Extrinsic motivation can foster effortful cognitive control. Moreover, the selective coupling of extrinsic motivation on low- versus high-control demands tasks would exert an additional impact. However, to what extent their influences are further modulated by the level of Need for Cognition (NFC) remains unclear.
View Article and Find Full Text PDFJ Neurosci
January 2025
Department of Psychology, McGill University, Montreal, QC, Canada.
Individuals avoid spending cognitive effort unless expected rewards offset the perceived costs. Recent work employing tasks that provide explicit information about demands and incentives, suggests causal involvement of the Frontopolar Cortex (FPC) in effort-based decision-making. Using transcranial direct current stimulation (tDCS), we examined whether the FPC's role in motivating effort generalizes to sequential choice problems in which task demand and reward rates vary indirectly and as a function of experience.
View Article and Find Full Text PDFBr J Soc Psychol
January 2025
Faculty of Psychology, University of Warsaw, Warsaw, Poland.
In three studies (total N = 622), the effects of threat to control on subsequent moral judgement were examined. After recalling a lack-of-control experience, participants evaluated the morality of a protagonist's decisions in a series of incongruent moral dilemmas. We found that a control-threatening reminder made moral judgements more utilitarian on the deontological-utilitarian dimension, which is consistent with the control motivation theory.
View Article and Find Full Text PDFJ Neurosci
January 2025
Centre for Human Brain Health, School of Psychology University of Birmingham, B15 2TT, UK.
Physiol Behav
December 2024
Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, UK; Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex, UK.
Fatigue may affect the decision to deploy effort (cost) for a given rewarded outcome (benefit). However, it remains unclear whether these fatigue-associated changes can be attributed to simply feeling fatigued. To investigate this question, twenty-two healthy males made a series of choices between two rewarded options: a fixed, no effort option, where no physical effort was required to obtain a set, low reward vs.
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