Risk factors associated with the need for mechanical ventilation in children with Guillain-Barré syndrome.

Zhongguo Dang Dai Er Ke Za Zhi

Department of Electrophysiology, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430016, China (Jiang J, com).

Published: September 2021

Objectives: To study the risk factors associated with the need for mechanical ventilation in children with Guillain-Barré syndrome (GBS).

Methods: The medical data of 107 children with GBS were retrospectively reviewed. According to whether mechanical ventilation was required, the children were divided into a mechanical ventilation group with 16 children and a non-mechanical ventilation group with 91 children. The risk factors associated with the need for mechanical ventilation in children with GBS were identified by a multivariate logistic regression analysis.

Results: Among the 107 children, 16 (15.0%) required mechanical ventilation. Compared with the non-mechanical ventilation group, the mechanical ventilation group had a significantly higher proportion of children with facial and/or bulbar muscle weakness, a significantly shorter duration from the onset to the peak of the disease, and a significantly higher Hughes Functional Grading Scale score at the first visit (<0.05). Facial and/or bulbar muscle weakness and short duration from the onset to the peak of the disease were risk factors associated with the need for mechanical ventilation in children with GBS (=5.053 and 1.239 respectively, <0.05).

Conclusions: Facial and/or bulbar muscle weakness and short duration from the onset to the peak of the disease may increase the risk of mechanical ventilation in children with GBS. .

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8480164PMC
http://dx.doi.org/10.7499/j.issn.1008-8830.2106003DOI Listing

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