AI Article Synopsis
- The study investigates the transfer of antibodies via breastmilk in lactating women after receiving the BNT162b2 Pfizer vaccine against COVID-19.
- It involves a cohort of 24 healthcare workers, comparing immunological responses between lactating and non-lactating women post-vaccination.
- Results show all participants developed immunity with detectable antibodies, while lactating mothers exhibited modest levels of antibodies in breastmilk, particularly IgG, with longer breastfeeding duration correlating with higher IgG levels.
Article Abstract
Background: Immunological protection via breastfeeding is well known. The immunological profile of human milk changes during lactation. No clinical trials have been conducted in lactating women with the newest mRNA vaccines against SARS- CoV-2. A Few studies have shown the presence of antibodies in breastmilk after vaccination. The aim of this work is to study possible antibodies transfer via breastmilk and also the immunological characteristics of lactating women compared to non-lactating women, after using the BNT162b2 Pfizer vaccine.
Methods: This is a prospective cohort study with a convenience homogenous sample of 24 healthcare workers (14 lactating and 10 non-lactating women) enrolled at the time of COVID-19 vaccination. Clinical data was registered in a questionnaire. Titers of SARS-CoV-2 spike IgG, IgA and IgM were quantified in post vaccination blood and human milk. Antibody quantification was performed by an in-house ELISA to SARS-CoV-2 trimeric spike protein.
Results: All women showed immunity after vaccination with positive antibodies for IgM, IgA and IgG antibodies. The dominant serum antibody response was IgG. Modest levels of antibodies in breastmilk of lactating mothers were observed in this study, especially IgG in 42.9%. There was a moderate association between higher titers of IgG and a longer duration of breastfeeding (R= 0.55, p=0.041).
Conclusions: Evidence of antibody transfer in human milk after COVID-19 vaccination is scarce. The presence of antibodies in human milk is reported, but immunization through breastfeeding is still to be established.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8447894 | PMC |
| http://dx.doi.org/10.1186/s12884-021-04051-6 | DOI Listing |
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