Myocarditis refers to myocardial inflammatory damage, and it can have various causes. Myocarditis can lead to impaired cardiac function, including decreased systolic and diastolic function and arrhythmia. When myocarditis occurs suddenly and rapidly progresses to severe heart failure, hypotension, cardiogenic shock, or severe arrhythmia, it can be diagnosed as fulminant myocarditis (FM). Our hospital recently admitted a case of juvenile FM, a 17-year-old male, who was admitted to the hospital for "intermittent chest tightness and asthma for 10 days". When the patient was hospitalized, he complained of chest tightness, palpitation, shortness of breath, fatigue, and dyspnea. Wet rales could be heard in both lungs on auscultation, as well as arrhythmia. Echocardiograms indicated an ejection fraction of 10%. Laboratory tests showed liver and kidney dysfunction as well as abnormal coagulation function. After admission, he was treated with drugs including cardiotonic, diuretic, hormonal, antiviral drugs, and drugs affecting immune regulation. After tracheal intubation-assisted ventilation, the patient's symptoms did not significantly alleviate, and then veno-arterial extracorporeal membrane oxygenation (V-A ECMO) combined with an intra-aortic balloon pump (IABP) were used to assist in the treatment of cardiopulmonary failure. After the treatment, the patient's hemodynamics were stable, the respiratory and circulatory functions were restored, and the ECMO and IABP were successfully removed. The patient's review results were satisfactory, and he was discharged without delay. Although ECMO has no direct therapeutic effect on myocarditis, it can quickly stabilize hemodynamics, improve systemic tissue perfusion, reduce the use of high-dose vasoactive drugs and effectively assist patients during the acute phase of myocarditis. The authors believe that ECMO is the first choice for the treatment of FM in adolescents. Here we summarize our experience at our hospital with the treatment of FM using life support methods.
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http://dx.doi.org/10.21037/atm-21-3959 | DOI Listing |
Children (Basel)
November 2024
Pediatric Emergency Unit, Santobono-Pausilipon Children's Hospital, 80129 Naples, Italy.
Acute fulminant myocarditis is a rare event in children, accounting for about 10% of all cases of acute myocarditis. Its lack of specific onset patterns and unpredictable evolution make diagnosis and prompt treatment challenging. We observed six cases of fulminant myocarditis admitted to our Pediatric Emergency Unit (Campania region, Sothern Italy) within a very short timeframe (50 days, from July to September 2024).
View Article and Find Full Text PDFZhonghua Bing Li Xue Za Zhi
January 2025
Department of Pathology, the Seventh Medical Center of People's Liberation Army of China General Hospital, Beijing100700, China.
To analyze the morphologic changes and the extent of severity in end-stage heart disease; and to explore the correlation with their clinical features. Twelve cases of recipients who underwent pediatric cardiac allograft transplantation were collected from May 2022 to November 2023 at the Seventh Medical Center of People's Liberation Army of China General Hospital. Gross pathologic examinations were performed and morphological changes were observed under a light microscope after HE, Masson's trichrome, and reticulin staining.
View Article and Find Full Text PDFIntern Med
January 2025
Department of Cardiovascular Medicine, Okayama City Hospital, Japan.
We herein report a case of Systemic Capillary Leak Syndrome (SCLS) attributed to coronavirus disease (COVID-19) that emerged in 2019. A 56-year-old woman presented with a COVID-19 infection 7 days prior to the visit with upper respiratory symptoms, fatigue, and decreased appetite. Secondary SCLS due to COVID-19 was diagnosed, veno-arterial extracorporeal membrane oxygenation (VA-ECMO) was initiated as mechanical support, and intravenous immunoglobulin was administered, marking the transition to the recovery phase with the initiation of fluid resuscitation.
View Article and Find Full Text PDFEur Heart J Case Rep
December 2024
Department of Cardiology, Tsuyama Chuo Hospital, 1756 Kawasaki, Tsuyama, Okayama 708-0841, Japan.
Background: Brugada phenocopy (BrP) is a condition that induces reversible Brugada-like electrocardiographic (ECG) changes in patients without true Brugada syndrome. We present two cases of fulminant eosinophilic myocarditis that showed Type 1 Brugada ECG changes in the early phase of the clinical course.
Case Summary: Case 1 was a 76-year-old man who developed fulminant eosinophilic myocarditis with ventricular tachycardia while hospitalized for heart failure.
Eur Heart J Case Rep
October 2024
Baker Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia.
Background: Fulminant eosinophilic myocarditis (EM) is a rare and often fatal condition that may present atypically and be complicated by ventricular arrhythmias. Treatment involves high-dose corticosteroids to suppress eosinophilia, as well as increasing use of mepolizumab, an anti-interleukin-5 antibody with evidence for long-term efficacy and safety.
Case Summary: A 38-year-old woman presented to the emergency department with neck pain and fatigue, and after extensive investigation was diagnosed with EM secondary to idiopathic hypereosinophilic syndrome.
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