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Biological Activities of Extracts from Ageratum fastigiatum: Phytochemical Study and In Silico Target Fishing Approach. | LitMetric

AI Article Synopsis

Article Abstract

In the present study, the ethanolic extract from aerial parts of was evaluated against epimastigote forms of (Y strain), promastigote forms of (PH8 strain), and (BH400 strain). The extract was also evaluated against (ATCC 25 923), (ATCC 11 775), (ATCC 10 145), and (ATCC 36 802). The phytochemical screening was performed by thin-layer chromatography and high-performance liquid chromatography. The extract was fractionated using flash preparative chromatography. The ethanolic extract showed activity against and and antimicrobial activity against and . The phytochemical screening revealed coumarins, terpenes/sterols, and flavonoids in the ethanolic extract. In addition, the coumarin identified as ayapin was isolated from this extract. We also performed prediction of potential biological activities and targets for compounds previously found in . Several predictions were confirmed both retrospectively and prospectively by experimental results described here or elsewhere. Some activities described in the target fishing approach were validated by the ethnopharmacological use and known biological properties. Some new activities and/or targets were predicted and could guide future studies. These results suggest that can be an interesting source of substances with antiparasitic and antimicrobial activities.

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http://dx.doi.org/10.1055/a-1576-4080DOI Listing

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