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Topical Caspofungin 0.5% Monotherapy for Filamentous Fungal Keratitis.
Cornea
January 2025
Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Purpose: To describe a case series of patients with 12 fungal keratitis treated with caspofungin 0.5% eye drops.
Methods: In this study, 12 patients diagnosed with fungal keratitis were treated with topical compounded caspofungin 0.
Analysis of choroidal thickness, macular thickness, peripapillary retinal nerve fiber layer thickness, and macular vascular density in children with unilateral amblyopia using swept-source optical coherence tomography and their changes following occlusion therapy.
Taiwan J Ophthalmol
June 2024
Department of Vitreo-Retina, Sankara Eye Hospital, Shimoga, Karnataka, India.
Purpose: The purpose of this study was to analyze choroidal thickness (CT), along with macular thickness (MT), peripapillary retinal nerve fiber layer thickness (RNFLT), and macular vascular density (MVD) using swept-source optical coherence tomography (SS-OCT) in children with unilateral amblyopia, and compare the same with normal fellow eyes and normal eyes of normal children before and following occlusion therapy.
Materials And Methods: This was a prospective, longitudinal study of 60 children (4-18 years); 30 children had unilateral amblyopia and remaining 30 were normal. Group 1 consisted of 30 amblyopic eyes of children with unilateral amblyopia; Group 2 consisted of 30 fellow normal eyes of Group 1; Group 3 consisted of normal eyes of normal children.
Y-27632 and dual media culture approach promote the construction and transplantation of rabbit limbal epithelial cell sheets via cell spheroid culture and auto-bioprinting.
Acta Biomater
January 2025
Ophthalmology Department, The First Affiliated Hospital of Jinan University, Guangzhou, China; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, Guangzhou, China; Institute of Ophthalmology, Medical College, Jinan University, Guangzhou, China; Aier School of Ophthalmology, Central South University, Changsha, China. Electronic address:
The shortage of corneal donors and the limitations in tissue engineering grafts, such as biocompatibility and mechanical properties, pose significant challenges in corneal transplantation. Here, for the first time, we investigate the effect of Rho kinase inhibitor Y-27632 and a dual media culture approach, including proliferative media (M1) and stabilizing media (M2), on rabbit limbal epithelial stem cells (LESCs), aiming to explore the feasibility of constructing corneal cell sheets in vitro through auto-bioprinting and assessing their corneal wound healing capacity in vivo. Y-27632 has primarily demonstrated significantly enhanced LESCs growth, proliferation, and reduced apoptosis.
View Article and Find Full Text PDFThe association between grade of coronary heart disease and risk of developing keratopathy: a nationwide cohort study.
Int J Med Sci
January 2025
Nobel Eye Institute, Taipei, Taiwan.
To evaluate the association between coronary heart disease (CHD) severity and the risk of developing keratopathy. A retrospective cohort study was conducted with data from the Taiwan National Health Insurance Research Database (NHIRD). A total of 593100, 593100 and 296500 patients were included in the control, mild CHD and severe CHD groups, respectively.
View Article and Find Full Text PDFEccentric Superficial Anterior Lamellar Keratoplasty for Bilateral Limbal Stem Cell Deficiency.
Cornea
November 2024
External Diseases. Moorfield's Eye Hospital, London, United Kingdom.
Purpose: To describe and report the outcomes of allogeneic eccentric superficial anterior lamellar keratoplasty (SALK), a novel surgical technique, in the management of total bilateral limbal stem cell deficiency (LSCD).
Methods: Data were collected retrospectively on all patients with total bilateral LSCD who underwent SALK. Previous surgery, preexisting glaucoma, conjunctivalization, vascularization, lens status, and preoperative best-corrected visual acuity (BCVA) were collected from medical notes.
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