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The evolution of the antimicrobial peptide database over 18 years: Milestones and new features. | LitMetric

The evolution of the antimicrobial peptide database over 18 years: Milestones and new features.

Protein Sci

Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, Nebraska, USA.

Published: January 2022

AI Article Synopsis

  • The antimicrobial peptide database (APD) has been foundational for the antimicrobial peptide field for 18 years, highlighting its significance in research and education.
  • The article reviews key milestones in the database's development, updates peptide statistics from 2010 to 2020, and introduces new features and entries, including those related to antimicrobial peptides from host microbiota.
  • The APD has been updated for better web access and security, and can now be found at https://aps.unmc.edu.

Article Abstract

The antimicrobial peptide database (APD) has served the antimicrobial peptide field for 18 years. Because it is widely used in research and education, this article documents database milestones and key events that have transformed it into the current form. A comparison is made for the APD peptide statistics between 2010 and 2020, validating the major database findings to date. We also describe new additions ranging from peptide entries to search functions. Of note, the APD also contains antimicrobial peptides from host microbiota, which are important in shaping immune systems and could be linked to a variety of human diseases. Finally, the database has been re-programmed to the web branding and latest security compliance of the University of Nebraska Medical Center. The reprogrammed APD can be accessed at https://aps.unmc.edu.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8740828PMC
http://dx.doi.org/10.1002/pro.4185DOI Listing

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