Individuals with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) may exhibit driving difficulties due to cognitive impairments such as time perception difficulties, a construct related to the perception of time-to-collision (TTC). This study examined the timing abilities of drivers with ASD and ADHD. Sixty participants (n = 20, n = 20, n = 20) completed a time reproduction task and a TTC estimation task in a driving simulator. Results indicated drivers with ASD were less precise in time reproduction across all time intervals and over-reproduced time at shorter intervals. Drivers with ASD produced larger TTC estimates when driving at a faster speed compared to typically developing drivers. Drivers with ASD, but not ADHD, appear to present difficulties in time estimation abilities.
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http://dx.doi.org/10.1007/s10803-021-05264-6 | DOI Listing |
J Hazard Mater
December 2024
Department of Pharmacology & Toxicology, University of Texas Medical Branch, Galveston, TX 77555, USA; Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:
Environmental exposure to pesticides at levels deemed safe by regulatory agencies has been linked to increased risk for neurodevelopmental disorders. Yet, the mechanisms linking exposure to these disorders remain unclear. Here, we show that maternal exposure to the pesticide deltamethrin (DM) at the no observed adverse effect level (NOAEL) disrupts long-term potentiation (LTP) in the hippocampus of adult male offspring three months after exposure, a phenotype absent in female offspring.
View Article and Find Full Text PDFBMC Psychiatry
December 2024
Faculty of Medicine and Health Technology, Tampere University and Tays Cancer Centre, Tampere, Finland.
Background: Autism spectrum disorder (ASD) is a partially heritable neurodevelopmental trait, and people with ASD may also have other co-occurring trait such as ADHD, anxiety disorders, depression, mental health issues, learning difficulty, physical health traits and communication challenges. The concomitant development of ASD and other neurological traits is assumed to result from a complex interplay between genetics and the environment. However, only a limited number of studies have performed multivariate genome-wide association studies (GWAS) for ASD.
View Article and Find Full Text PDFJ Neurosci
November 2024
Institute of Neuroscience, CNR, Vedano al Lambro, Italy.
Protocadherins, a family of adhesion molecules with crucial role in cell-cell interactions, have emerged as key players in neurodevelopmental and psychiatric disorders. In particular, growing evidence links genetic alterations in Protocadherin 9 () gene with Autism Spectrum Disorder (ASD) and Major Depressive Disorder (MDD). Furthermore, deletion induces neuronal defects in the mouse somatosensory cortex, accompanied by sensorimotor and memory impairment.
View Article and Find Full Text PDFAgron Sustain Dev
November 2024
Soil & Crop Sciences, Cornell University, Ithaca, USA.
Unlabelled: Far removed from the agricultural fire "hotspots" of Northwestern India, rice residue burning is on the rise in Eastern India with implications for regional air quality and agricultural sustainability. The underlying drivers contributing to the increase in burning have been linked to the adoption of mechanized (combine) harvesting but, in general, are inadequately understood. We hypothesize that the adoption of burning as a management practice results from a set of socio-technical interactions rather than emerging from a single factor.
View Article and Find Full Text PDFCell Rep Med
November 2024
Oncology R&D, AstraZeneca, Waltham, MA, USA. Electronic address:
In cancer, chronic antigen stimulation drives effector T cells to exhaustion, limiting the efficacy of T cell therapies. Recent studies have demonstrated that epigenetic rewiring governs the transition of T cells from effector to exhausted states and makes a subset of exhausted T cells non-responsive to PD1 checkpoint blockade. Here, we describe an antigen-specific assay for T cell exhaustion that generates T cells phenotypically and transcriptionally similar to those found in human tumors.
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