A new homocysteine thiolactone derivative, thiolactomide (1), was isolated along with a known compound, -acetyl homocysteine thiolactone (2), from a culture extract of soil-derived sp. RK88-1441. The structures of these compounds were elucidated by detailed NMR and MS spectroscopic analyses with literature study. In addition, biological evaluation studies revealed that compounds 1 and 2 both exert neuroprotective activity against 6-hydroxydopamine (6-OHDA)-mediated neurotoxicity by blocking the generation of hydrogen peroxide in neuroblastoma SH-SY5Y cells.
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| http://dx.doi.org/10.4014/jmb.2108.08015 | DOI Listing |
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