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| http://dx.doi.org/10.3389/fphys.2021.745887 | DOI Listing |
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O-GlcNAcylation dictates pyroptosis.
Front Immunol
January 2025
Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, China.
Article Synopsis
- O-GlcNAcylation is a modification that adds a sugar molecule, N-acetylglucosamine, to specific amino acids, influencing signaling pathways important for pyroptosis, a form of cell death.
- Enhancing O-GlcNAcylation of the protein GSDMD is suggested as a key strategy for improving blood flow issues in sepsis, while GSDME's role in macrophage pyroptosis is linked to high glucose levels in periodontitis.
- The review discusses O-GlcNAcylation's impact on the NLRP3 inflammasome and other regulators, highlighting its potential as a therapeutic target for diseases like sepsis and osteoarthritis by managing inflammation.
Protein shapeshifting in necroptotic cell death signaling.
Trends Biochem Sci
December 2024
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia. Electronic address:
Necroptosis is a mode of programmed cell death executed by the mixed lineage kinase domain-like (MLKL) pseudokinase following its activation by the upstream receptor-interacting protein kinase-3 (RIPK3), subsequent to activation of death, Toll-like, and pathogen receptors. The pathway originates in innate immunity, although interest has surged in therapeutically targeting necroptosis owing to its dysregulation in inflammatory diseases. Here, we explore how protein conformation and higher order assembly of the pathway effectors - Z-DNA-binding protein-1 (ZBP1), RIPK1, RIPK3, and MLKL - can be modulated by post-translational modifications, such as phosphorylation, ubiquitylation, and lipidation, and intermolecular interactions to tune activities and modulate necroptotic signaling flux.
View Article and Find Full Text PDFFunctional interaction of melatonin with gasotransmitters and ROS in plant adaptation to abiotic stresses.
Front Plant Sci
December 2024
Institute of Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Kyiv, Ukraine.
Melatonin is considered a multifunctional stress metabolite and a novel plant hormone affecting seed germination, root architecture, circadian rhythms, leaf senescence, and fruit ripening. Melatonin functions related to plant adaptation to stress stimuli of various natures are considered especially important. One of the key components of melatonin's stress-protective action is its ability to neutralise reactive oxygen species (ROS) and reactive nitrogen species directly.
View Article and Find Full Text PDFEditorial: Community series in post-translational modifications of proteins in cancer immunity and immunotherapy, volume III.
Front Immunol
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School of Pharmaceutical Science and Technology, Faculty of Medicine, Tianjin University, Tianjin, China.
Channel Gating in a Post-Translational Protein Translocase.
Biochemistry
December 2024
Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
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