Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8439425 | PMC |
Publication Analysis
Top Keywords
Similar Publications
miR-9-5p/HMMR regulates the tumorigenesis and progression of clear cell renal cell carcinoma through EMT and JAK1/STAT1 signaling pathway.
J Transl Med
January 2025
Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Qingchun Road 79, Hangzhou, Zhejiang, 310003, China.
Background: The most common malignant type of kidney cancer is clear cell renal cell carcinoma (ccRCC). The expression levels of hyaluronan-mediated motility receptor (HMMR) in many tumor types are significantly elevated. HMMR is closely associated with tumor-related progression, treatment resistance, and poor prognosis, and has yet to be fully investigated in terms of its expression patterns and molecular mechanisms of action in ccRCC.
View Article and Find Full Text PDFConcurrent effects and dynamic wetting abilities of nanometals anchored redox-active Janus nanoarchitectures on cotton fabric for sustainable catalysis and disinfection.
Int J Biol Macromol
December 2024
Hubei Key Laboratory of Advanced Textile Materials & Application, Hubei International Scientific and Technological Cooperation Base of Intelligent Textile Materials & Application, Key Laboratory of Textile Fiber & Product, Ministry of Education, Wuhan Textile University, Wuhan 430200, China; School of Materials Science & Engineering, Hubei University of Automotive Technology, Shiyan 442002, China. Electronic address:
Article Synopsis
- Designed a new type of catalyst using a unique Lous-leaf-inspired nanoarchitecture that prevents contamination and improves efficiency in disinfection processes.
- Utilized hydrophilic polydopamine to help create a special coating on cotton fabric that interacts well with contaminants and boosts antibacterial action, all without needing extra chemicals.
- Achieved over 99% antibacterial effectiveness against E. coli even after multiple washes, demonstrating strong resistance and the ability to tackle common challenges in catalytic reactions.
Pan-cancer single cell and spatial transcriptomics analysis deciphers the molecular landscapes of senescence related cancer-associated fibroblasts and reveals its predictive value in neuroblastoma via integrated multi-omics analysis and machine learning.
Front Immunol
December 2024
Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, China.
Introduction: Cancer-associated fibroblasts (CAFs) are a diverse group of cells that significantly contribute to reshaping the tumor microenvironment (TME), and no research has systematically explored the molecular landscapes of senescence related CAFs (senes CAF) in NB.
Methods: We utilized pan-cancer single cell and spatial transcriptomics analysis to identify the subpopulation of senes CAFs via senescence related genes, exploring its spatial distribution characteristics. Harnessing the maker genes with prognostic significance, we delineated the molecular landscapes of senes CAFs in bulk-seq data.
Sensing Hachimoji DNA Bases with Janus MoSH Monolayer Nanodevice: Insights from Density Functional Theory (DFT) and Non-Equilibrium Green's Function Analysis.
ACS Omega
December 2024
Physical Sciences and Engineering Division, Kaust Catalysis Center, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
Detection of nucleobases is of great significance in DNA sequencing, which is one of the main goals of the Human Genome Project. The synthesis of Hachimoji DNA, an artificial genetic system with eight nucleotide bases, has induced a transformative shift in genetic research and biosensing. Here, we present a systematic investigation of the adsorption behavior and electronic transport properties of natural and modified DNA bases on a Janus molybdenum sulfur hydride (MoSH) monolayer using density functional theory (DFT) and nonequilibrium Green's function (NEGF) methods.
View Article and Find Full Text PDFGene-engineered polypeptide hydrogels with on-demand oxygenation and ECM-cell interaction mimicry for diabetic wound healing.
Biomaterials
May 2025
Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics - Hubei Bioinformatics & Molecular Imaging Key Laboratory, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, Hubei, PR China. Electronic address:
Article Synopsis
- The treatment of infected diabetic wounds is complicated due to infection, inflammation, and issues with blood vessel growth and cellular interactions.
- Researchers have developed a Janus polypeptide-engineered hydrogel that combines two layers: one that targets bacteria and another that supplies oxygen to promote healing.
- The hydrogel has shown significant improvements in wound healing rates and enhances skin structure reconstruction by reducing inflammation and supporting healthy cell interactions.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!